Tumor Regression Grade Predicts Survival in Locally Advanced Gastric Adenocarcinoma Patients with Lymph Node Metastasis

Table 4

Multivariate analysis of patients with lymph node metastasis.

Prognostic factors	OS		DFS
	Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
Age	1.815 (1.197, 2.752)	0.005	1.396 (0.932, 2.091)	0.105
Tumor location		0.128		0.053
L	1		1
M	0.626 (0.358, 1.094)	0.100	0.597 (0.342, 1.040)	0.068
U	1.196 (0.593, 2.413)	0.618	1.057 (0.532, 2.100)	0.873
GEJ	1.139 (0.511, 2.539)	0.750	1.260 (0.599, 2.651)	0.542
Diffuse	1.676 (0.932, 3.014)	0.085	1.809 (1.029, 3.012)	0.040
Tumor size (cm)	2.093 (1.276, 3.431)	0.003	1.864 (1.153, 3.012)	0.011
ypT		0.693		0.458
0	1		1
1-2	0.907 (0.098, 8.431)	0.932	1.009 (0.112, 9.109)	0.994
3-4	0.366 (0.019, 7.221)	0.509	0.280 (0.015, 5.128)	0.391
ypTNM	2.432 (0.305, 19.371)	0.401	3.079 (0.424, 22.371)	0.266
Histological type	0.913 (0.603, 1.380)	0.665	0.808 (0.539, 1.213)	0.304
Lauren classification	1.517 (0.964, 2.389)	0.072	1.431 (0.919, 2.227)	0.113
Grade of differentiation	1.360 (0.673, 2.749)	0.392	1.228 (0.630, 2.393)	0.546
Vascular or lymphatic invasion	1.903 (1.265, 2.862)	0.002	1.635 (1.101, 2.427)	0.015
Nervous invasion	1.003 (0.662, 1.520)	0.988	0.993 (0.662, 1.490)	0.973
Mandard TRG	2.034 (1.052, 3.934)	0.035	2.220 (1.162, 4.241)	0.016
Adjuvant treatment	2.464 (1.393, 4.358)	0.002	2.339 (1.337, 4.092)	0.003