Gastroenterology Research and Practice

Research Article

Correlation of Serum Cardiac Markers with Acute Decompensating Events in Liver Cirrhosis

Table 2

Comparison of characteristics of cirrhotic patients with ascites, acute gastrointestinal hemorrhage, ACLF, and without decompensating events.


Variables	With ascites			With acute gastrointestinal hemorrhage			With ACLF
Variables	No. Pts	; median (range) or frequency (percentage)	value	No. Pts	; median (range) or frequency (percentage)	value	No. Pts	; median (range) or frequency (percentage)	value

Sex (male/female), (%)	96	64 (66.67%)/32 (33.33%)	0.064	86	56 (65.12%)/30 (34.88%)	0.039	10	8 (80%)/2 (20%)	0.558
Age (years)	96	; 60.00 (48.00-65.75)	0.027	86	; 54.00 (45.00-63.25)	0.692	10	; 48.00 (45.00-57.00)	0.429
Red blood cell (10¹²/L)	96	; 3.08 (2.57-3.83)	<0.001	86	; 2.75 (2.39-3.35)	<0.001	10	; 2.60 (1.78-3.45)	<0.001
Hemoglobin (g/L)	96	; 93.00 (70.00-113.75)	<0.001	86	; 76.00 (66.00-99.00)	<0.001	10	; 98.50 (65.25-117.25)	0.018
Hematocrit (%)	96	; 28.40 (21.38-34.33)	<0.001	86	; 23.15 (20.33-30.20)	<0.001	10	; 28.80 (18.58-34.75)	0.004
White blood cell (10⁹/L)	96	; 3.85 (2.73-6.18)	0.119	86	; 3.60 (2.38-6.30)	0.390	10	; 6.15 (4.43-8.25)	0.021
Platelet count (10⁹/L)	96	; 78.00 (54.00-106.75)	0.384	86	; 72.50 (51.00-103.75)	0.755	10	; 64.50 (39.00-97.25)	0.562
Total bilirubin (μmol/L)	96	; 28.90 (15.38-63.15)	0.186	86	; 19.55 (13.20-32.20)	0.292	10	; 166.20 (121.25-223.50)	<0.001
Direct bilirubin (μmol/L)	96	; 13.45 (6.43-37.53)	0.039	86	; 8.45 (5.40-16.23)	0.582	10	; 105.10 (82.08-184.23)	<0.001
Alanine aminotransferase (U/L)	96	; 23.09 (16.25-39.37)	0.517	86	; 20.92 (14.62-36.63)	0.132	10	; 51.43 (23.77-63.76)	0.012
Aspartate aminotransferase (U/L)	96	; 34.56 (24.01-68.95)	0.404	86	; 27.45 (20.43-48.41)	0.232	10	; 93.55 (65.65-128.31)	<0.001
Alkaline phosphatase (U/L)	96	; 101.99 (75.12-149.67)	0.621	86	; 81.09 (59.99-110.37)	0.019	10	; 137.08 (84.14-169.98)	0.202
Gamma-glutamyl transpeptidase (U/L)	96	; 46.21 (21.10-108.21)	0.901	86	; 29.01 (16.74-57.98)	0.032	10	; 67.05 (37.05-97.91)	0.218
Albumin (g/L)	96	; 29.65 (25.10-33.40)	<0.001	86	; 31.10 (25.68-36.18)	<0.001	10	; 22.80 (19.95-26.98)	<0.001
Blood urea nitrogen (mmol/L)	96	; 6.05 (4.42-7.86)	0.007	86	; 6.25 (4.39-8.46)	0.003	10	; 6.26 (4.78-11.15)	0.070
Creatinine (μmol/L)	96	; 63.55 (53.23-82.68)	0.686	86	; 65.86 (52.78-75.94)	0.895	10	; 61.15 (52.53-101.95)	0.763
eGFR (mL/min/1.73 m²)	96	; 104.38 (77.60-133.84)	0.047	86	; 108.07 (86.83-138.32)	0.247	10	; 107.84 (73.24-137.83)	0.403
Na (mmol/L)	96	; 137.75 (134.93-140.95)	0.041	86	; 139.35 (136.55-141.03)	0.741	10	; 135.20 (131.55-139.15)	0.021
Prothrombin time (second)	96	; 17.15 (15.60-20.45)	0.001	86	; 16.90 (15.20-19.10)	0.026	10	; 22.85 (20.65-27.95)	<0.001
Activated partial thromboplastin time (second)	96	; 41.90 (37.73-47.28)	0.987	86	; 39.70 (36.98-43.98)	0.064	10	; 52.85 (46.63-55.95)	<0.001
International normalized ratio	96	; 1.40 (1.25-1.75)	0.001	86	; 1.37 (1.21-1.60)	0.031	10	; 1.99 (1.77-2.59)	<0.001
D-dimer (mg/L)	95	; 2.28 (0.93-4.64)	<0.001	83	; 1.43 (0.58-3.57)	0.001	9	; 4.51 (3.41-9.02)	<0.001
High-sensitivity C-reactive protein (mg/L)	95	; 6.90 (2.20-20.30)	0.001	85	; 4.50 (1.20-11.55)	0.071	10	; 30.65 (11.35-75.35)	<0.001
MELD score	96	; 13.50 (10.07-18.23)	0.001	86	; 10.65 (9.13-14.42)	0.343	10	; 28.14 (21.24-30.04)	<0.001
Child-Pugh score	96	; 8.00 (7.00-10.00)	<0.001	86	; 7.00 (6.00-8.00)	<0.001	10	; 12.00 (11.75-13.00)	<0.001
NT-pro BNP (pg/mL)	87	; 165.20 (71.06-415.80)	<0.001	78	; 144.95 (60.82-443.93)	<0.001	10	; 212.30 (150.70-1662.75)	<0.001
High-sensitivity cardiac troponin T (ng/mL)	92	; 0.008 (0.005-0.014)	0.002	81	; 0.009 (0.005-0.014)	0.003	9	; 0.007 (0.005-0.035)	0.157
Creatine kinase (U/L)	95	; 69.00 (45.00-97.00)	0.099	84	; 69.00 (40.50-105.50)	0.117	10	; 71.50 (41.25-109.00)	0.501
Creatine kinase MB (U/L)	95	; 29.00 (20.00-42.00)	0.463	84	; 29.50 (19.00-43.75)	0.552	10	; 22.50 (14.50-36.00)	0.163
Lactate dehydrogenase (U/L)	95	; 195.00 (154.00-232.00)	0.076	84	; 171.00 (140.00-206.25)	0.727	10	; 235.00 (157.50-317.25)	0.050

Bold font indicates statistically significant values. Abbreviations: ACLF: acute-on-chronic liver failure; eGFR: the estimated glomerular filtration rate; MELD: model for end-stage liver disease; NT-pro BNP: N-Terminal pro-B-type natriuretic peptide.