Correlation of Serum Cardiac Markers with Acute Decompensating Events in Liver Cirrhosis

Table 3

Partial correlation analysis of the NT-pro BNP level in cirrhosis.

Variables	All liver cirrhosis			Liver cirrhosis without decompensation			Liver cirrhosis with decompensation
	No. Pts	value	Correlation coefficient	No. Pts	value	Correlation coefficient	No. Pts	value	Correlation coefficient
Age (years)	/	Controlling	/	/	Controlling	/	/	Controlling	/
Sex (male/female), (%)	/	Controlling	/	/	Controlling	/	/	Controlling	/
Red blood cell (10^12/L)	154	<0.001	-0.322	34	0.023	-0.379	116	0.001	-0.313
Hemoglobin (g/L)	154	0.004	-0.229	34	0.001	-0.540	116	0.025	-0.207
Hematocrit (%)	154	0.001	-0.254	34	0.001	-0.523	116	0.011	-0.234
White blood cell (10^9/L)	154	0.027	0.177	34	0.093	-0.284	116	0.058	0.175
Platelet count (10^9/L)	154	0.894	-0.011	34	0.201	-0.218	116	0.842	-0.018
Total bilirubin (μmol/L)	154	0.027	0.178	34	0.755	-0.054	116	0.054	0.178
Direct bilirubin (μmol/L)	154	0.063	0.149	34	0.661	-0.076	116	0.113	0.146
Alanine aminotransferase (U/L)	154	0.715	-0.029	34	0.534	-0.107	116	0.609	-0.048
Aspartate aminotransferase (U/L)	154	0.694	-0.032	34	0.493	-0.118	116	0.687	-0.037
Alkaline phosphatase (U/L)	154	0.534	-0.050	34	0.071	-0.304	116	0.623	-0.046
Gamma-glutamyl transpeptidase (U/L)	154	0.983	-0.002	34	0.206	-0.216	116	0.794	0.024
Albumin (g/L)	154	0.006	-0.219	34	0.263	-0.192	116	0.042	-0.188
Blood urea nitrogen (mmol/L)	154	0.022	0.183	34	0.099	0.279	116	0.074	0.165
Creatinine (μmol/L)	154	0.692	-0.032	34	0.755	-0.054	116	0.547	-0.056
eGFR (mL/min/1.73 m^2)	154	0.073	0.144	34	0.823	0.039	116	0.058	0.175
Sodium (mmol/L)	154	0.039	-0.165	34	0.586	0.094	116	0.082	-0.161
Prothrombin time (second)	154	<0.001	0.416	34	0.480	0.122	116	<0.001	0.419
Activated partial thromboplastin time (second)	154	0.023	0.182	34	0.406	0.143	116	0.030	0.200
International normalized ratio	154	<0.001	0.436	34	0.380	0.151	116	<0.001	0.439
D-dimer (mg/L)	153	0.003	0.241	34	0.125	0.260	115	0.040	0.190
High-sensitivity C-reactive protein (mg/L)	153	<0.001	0.285	33	0.576	0.098	116	0.003	0.270
MELD score	154	<0.001	0.302	34	0.701	0.066	116	0.001	0.296
Child-Pugh score	154	<0.001	0.346	34	0.279	0.185	116	<0.001	0.325
High-sensitivity cardiac troponin T (ng/mL)	151	0.004	0.229	34	0.062	-0.315	113	0.026	0.208
Creatine kinase (U/L)	154	0.653	-0.036	34	0.567	0.099	116	0.588	-0.050
Creatine kinase MB (U/L)	154	0.209	-0.101	34	0.744	-0.056	116	0.217	-0.115
Lactate dehydrogenase (U/L)	154	0.622	-0.040	34	0.985	-0.003	116	0.586	-0.051

Bold font indicates statistically significant values. Abbreviations: NT-pro BNP: N-Terminal pro-B-type natriuretic peptide; eGFR: the estimated glomerular filtration rate; MELD: model for end-stage liver disease.