Review Article

Claudin-1 Is a Valuable Prognostic Biomarker in Colorectal Cancer: A Meta-Analysis

Table 2

Meta-analysis of the correlation between claudin-1 expression and clinicopathological factors of colorectal cancer.

Clinicopathological parameterNo. of studiesParticipantsRR (95% CI)Analysis modelHeterogeneityTest for overall effect
(%) value test value

Tumor type (poorly vs. well)613120.60 (0.49, 0.73)Fixed330.194.94<0.00001
Venous invasion (+ vs. -)410290.81 (0.70, 0.95)Fixed00.401.590.0010
Lymphatic invasion (+ vs. -)410280.83 (0.74, 0.92)Fixed00.423.320.0009
Perineural invasion (+ vs. -)25660.57 (0.25, 1.31)Random800.031.330.18
Depth of invasion (T3, 4 vs. T1, 2)410290.94 (0.72, 1.22)Random700.020.470.64
Lymph node metastasis (+ vs. -)410290.91 (0.82, 1.02)Fixed00.601.660.10
Distant metastasis (+ vs. -)23790.88 (0.67, 1.15)Fixed00.500.940.35
TNM stage (III, IV vs. I, II)37220.75 (0.54, 1.04)Random690.041.710.09
Size (larger vs. smaller)22750.88 (0.60, 1.29)Fixed00.680.650.52
Gender (male vs. female)511851.02 (0.92, 1.14)Fixed00.440.430.66
Age (older vs. younger)22751.15 (0.83, 1.60)Fixed00.500.970.33
Tumor site (colon vs. rectum)25001.01 (0.87, 1.17)Fixed00.810.100.92

RR: risk ratio; Random, random effects model; Fixed: fixed effect model.