Risk Factors for Mortality in Patients with Aortoesophageal Fistula Related to Aortic Lesions
Table 5
Cox regression analyses.
Univariable Cox regression
Multivariable Cox regression
HR
95% CI
HR
95% CI
Age
1.027
1.011-1.043
0.001
1.004
0.988-1.021
0.587
Hemorrhagic shock
2.124
1.444-3.123
<0.001
1.824
1.217-2.735
0.004
Contrast leak in CT†
2.102
1.134-3.897
0.018
Aneurysm size†
1.155
1.044-1.279
0.005
Sepsis
1.900
1.291-2.795
0.001
1.714
1.112-2.641
0.015
Multiorgan failure
3.544
1.872-6.710
<0.001
3.060
1.470-6.368
0.003
Aortic rupture
3.186
1.289-7.786
0.012
2.410
0.949-6.117
0.064
Conservative treatment
6.570
4.459-9.681
<0.001
5.257
3.405-8.116
<0.001
Aortic graft+esophagectomy
0.214
0.099-0.460
<0.001
0.319
0.125-0.813
0.017
TEVAR+aortic graft±esophageal treatments
0.424
0.186-0.968
0.042
0.493
0.172-1.415
0.189
AEF: aortoesophageal fistula; TEVAR: thoracic endovascular aortic repair; CT: computed tomography; HR: hazard ratio; CI: confidence interval. †Contrast leak in CT and aneurysm size were excluded from multivariate regression analysis due to the lack of information in more than 15% of patients with AEF.