Erratum | Open Access
Tilo Wuensch, Jonas Wizenty, Janina Quint, Wolfgang Spitz, Madeleen Bosma, Olaf Becker, Andreas Adler, Wilfried Veltzke-Schlieker, Martin Stockmann, Sascha Weiss, Matthias Biebl, Johann Pratschke, Felix Aigner, "Erratum to “Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer”", Gastroenterology Research and Practice, vol. 2020, Article ID 8691904, 3 pages, 2020. https://doi.org/10.1155/2020/8691904
Erratum to “Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer”
In the article titled “Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer” , there were errors in Figures 2 and 3 and Section 3.5. The corrected figures are shown below and are listed as Figures 2 and 3. Also, the incorrect value in Section 3.5 is corrected below.
3.5 FNDC and GPR116 Expression in GEO Data Sets
Publicly available data sets of the GEO database were analyzed to complement our findings with previous comparable studies. First, the microarray expression of FNDCs in seven human colonic tumor cell lines from the NCI-60 panel was obtained (GDS4296) . All FNDCs were expressed, whereas FNDC3A displayed the highest expression values (mean 2.4-fold higher) in all cell lines (Figure 4(a)). Significant expression differences () in analyzed cell lines were found regarding FNDC3A and FNDC3B (significance bars are not shown for overview purposes). In the microsatellite-unstable colorectal cancer data set (GDS4515) of human MSI CRC samples (), we analyzed the gene expressions compared to nonaffected colonic mucosa () . The expression data of FNDC3A, FNDC3B, FNDC4, and GPR116 were available and showed a small but significant downregulation of FNDC4 in MSI CRCs (, Figure 4(b)), while FNDC3A () and FNDC3B () remained unchanged. GPR116 was significantly upregulated (). To test for possible confounding by age or sex, we analyzed expression data in early- and late-onset CRCs in females () and males (), diagnosed at an age of 28-53 years () or 69-87 years () (GDS5232) . Data were available for FNDC3A, FNDC4, and GPR116, which showed neither age- (, , and ) nor sex-dependent differences (, , and ).
- T. Wuensch, J. Wizenty, J. Quint et al., “Expression analysis of fibronectin type III domain-containing (FNDC) genes in inflammatory bowel disease and colorectal Cancer,” Gastroenterology Research and Practice, vol. 2019, 11 pages, 2019.
Copyright © 2020 Tilo Wuensch et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.