Novel Pathologic Factors for Risk Stratification of Gastric “Indefinite for Dysplasia” Lesions

Figure 1

Representative images of structural atypia area (red-lined inner area) and area with total indefinite for dysplasia (black-lined inner area) In the red-lined inner area, one or more of the following are seen: variable glandular size, irregular glandular arrangement, glandular branching/budding, and glandular cribriform. In the black-lined inner area, one or more of structural or nuclear atypia are visible. (a) Structural atypia was present in 6.18% of the area, with a final diagnosis of nonneoplasm (hematoxylin and eosin; ×40 magnification). (b) The area ratio of the structural atypia was 61.1%, with a final diagnosis of carcinoma (hematoxylin and eosin; ×40 magnification). (c) A representative image of an area of nuclear atypia without structural atypia. Loss of surface maturation (arrow), nuclear enlargements, and hyperchromasia are visible (hematoxylin and eosin; ×100 magnification). (d) A representative image of an area of structural atypia. Glandular variation in size, irregular arrangement, and branching/budding (arrow) are visible (hematoxylin and eosin; ×200 magnification).

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