Circular RNA CDR1as Inhibits the Metastasis of Gastric Cancer through Targeting miR-876-5p/GNG7 Axis

Figure 2

CDR1as overexpression inhibits metastasis of GC cells in vitro and in vivo. (a) The fluorescence intensity of GFP in MKN-45, SGC-7901, and BGC-823 cells after lentivirus-mediated transfection. (b) RT-qPCR analysis of CDR1as level in CDR1as stably overexpressing cell lines and control cells. (c, d) Migration and invasion assays in MKN-45, SGC-7901, and BGC-823 cells with CDR1as overexpression. (e) Western blot analysis for E-cadherin, N-cadherin, vimentin, and MMP expression levels after CDR1as overexpression. (f) The macroscopic appearance of the abdominal metastasis model in nude mice. Red arrows indicate abdominal metastatic nodules. All values are expressed as the () (, , and ).

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