DDIT4 Novel Mutations in Pancreatic Cancer

Figure 2

The level of DDIT4 and gene mutation/pathological grading. (a) Immunohistochemistry revealed upregulation of DDIT4 in poorly differentiated adenocarcinoma tissue, moderately differentiated adenocarcinoma tissue, and solid pseudopapilloma tissue compared with adjacent normal tissues. (b) The level of DDIT4 increased in DDIT4 3-UTR gene mutation (990.T>A;1246.C>T) compared with pancreatic cancer tissues without gene mutation. The expression level of DDIT4 increased both in the cytoplasm and nucleus.

(a)

(b)