Prognostic Value of TRPM7 Expression and Factor XIIIa-Expressing Tumor-Associated Macrophages in Gastric Cancer

Figure 2

The differences of CD4⁺ TIL density according to classical prognostic parameters. (a) The density of CD4⁺ TILs was higher in patients with lymphovascular invasion (4.0, (range 7.0)) compared to those without (2.0, (range 5.0)) (, Mann-Whitney ). (b) As the depth of tumor invasion increased, the density of CD4⁺ TILs increased (, , , and ) (, ANOVA). (c) There was a positive correlation between lymph node metastasis and high CD4⁺ TIL density (, ANOVA). (d) Similarly, TNM stage IV patients had a more intense infiltration of CD4⁺ TILs () compared to TNM stage I patients () (, ANOVA). In the post hoc test (Bonferroni), it was determined that there is a statistically significant difference in terms of CD4⁺ TIL density especially between stage IV patients and early stage (stage I-II) patients ( and , respectively). According to Kaplan-Meier analysis, the high CD4⁺ TIL density was significantly associated with both (e) overall () and (f) disease-free survival (, log rank).

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