Clinical Features, Endoscopic Findings, and Predictive Factors for Mortality in Tissue-Invasive Gastrointestinal Cytomegalovirus Disease between Immunocompetent and Immunocompromised Patients
Table 5
Univariate and multivariate analyses (Cox proportional hazard model) to determine the predictive factors for inhospital mortality.
Variable factor
Univariate value
Multivariate† value
Hazard ratio (95% CI)
Immune status
0.722
-
Advanced age (>65 years)
0.045
0.594
0.85 (0.47-1.54)
ICU admission
<0.001
<0.001
7.21 (2.55-20.36)
HIV infection
0.431
-
-
Solid/hematologic cancer
0.003
0.530
0.77 (0.34-1.76)
Immunosuppressive agents
0.225
-
-
Chemotherapy
0.01
0.006
5.2 (1.89-14.29)
Low-dose prednisolone
0.384
-
-
Sepsis/shock
<0.001
0.025
1.98 (1.08-3.66)
CKD/ESRD
0.004
0.299
1.38 (0.75-2.52)
Respiratory failure
<0.001
0.148
1.62 (0.83-3.13)
Cirrhosis
0.472
-
-
Neutropenia
0.059
0.160
2.0 (0.79-5.04)
Bedridden
0.997
-
-
Inflammatory bowel disease
0.537
-
-
Autoimmune diseases
0.923
-
-
Diabetes mellitus
0.087
0.294
1.62 (0.68-3.82)
Malnutrition status
<0.001
0.040
2.62 (1.05-7.01)
†Variables with a value less than 0.2 were included for the multivariate analysis using the Cox proportional hazard regression model. Abbreviations: ICU: intensive care unit; HIV: human immunodeficiency virus; CKD: chronic kidney disease; ESRD: end-stage renal disease.
