Gastroenterology Research and Practice

Gut Microbiota and Metagenomic Advancement in Digestive Disease


Publishing date
17 Jun 2016
Status
Published
Submission deadline
29 Jan 2016

Lead Editor

1Washington University, Saint Louis, USA

2University of Alberta, Edmonton, Canada

3Huazhong Science and Technology University, Wuhan, China

4University of Louisville, Louisville, USA

5Texas A&M University, Houston, USA


Gut Microbiota and Metagenomic Advancement in Digestive Disease

Description

The human gut is home to complex and diverse communities of microbiota that contribute to the overall homeostasis of the host. Increasingly, the intestinal microbiota is recognized as an important player in human illness, particularly in many digestive diseases with mystic etiologies, such as malnutrition (both under and over), nonalcohol fatty liver disease (NAFLD), inflammatory bowel disease (IBD), and colorectal cancer (CRC). Until recently, much of our understanding of the complexity and diversity of the microorganisms in the gastrointestinal tract relied on observations from microbiological culture. However, unwinding of metagenomics utilizing culture-independent molecular methods based on the highly conserved bacterial 16S ribosomal RNA gene and advances in parallel large-scale deep sequencing technology have allowed more in-depth studies on the gut microbiota in the digestive diseases.

By utilizing high-throughput sequencing technologies, recent studies have explored compositional changes in the gut microbiota and identified potential pathogenic components from candidate bacterial species in certain digestive diseases, especially in IBD and NAFLD. Studies also have been attempted to clarify the utility of fecal microbiota transplantation and modulation for treatment of gastrointestinal and other organ system diseases. In the perspective of metagenomics in the gut microbiota, future studies have been expected to advance our understanding in etiology and pathogenesis and to develop new therapeutic strategies for a wide spectrum of human illness, including certain refractory digestive diseases.

In this special issue of this journal, we would like to present recent advances in research of the gut microbiota in gastrointestinal and liver diseases. Studies with metagenomics and functional analysis of gut microbiota to elucidate epidemiology, genetics, genomics, epigenomics, transcriptomics, and proteomics would feature this special issue very well.

We invite investigators to contribute original research articles and review articles focused on gut microbiota and digestive diseases in patients and animal models.

Potential topics include, but are not limited to:

  • Epidemiology in a variety of global populations
  • Metagenomics analysis of gut microbiota
  • Functional analysis of potential causal bacterial species
  • Epigenomics, transcriptomics, and proteomics profiling
  • New therapeutic strategies attempting to modulate gut microbiota
  • Method development for metagenomics and functional analysis

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 4703406
  • - Editorial

Gut Microbiota and Metagenomic Advancement in Digestive Disease

Jinsheng Yu | Sharon Marsh | ... | Chaodong Wu
  • Special Issue
  • - Volume 2016
  • - Article ID 2862173
  • - Review Article

The Pathogenesis of Nonalcoholic Fatty Liver Disease: Interplay between Diet, Gut Microbiota, and Genetic Background

Jinsheng Yu | Sharon Marsh | ... | Chaodong Wu
  • Special Issue
  • - Volume 2016
  • - Article ID 2687605
  • - Clinical Study

Fecal Microbiota Transplantation Using Upper Gastrointestinal Tract for the Treatment of Refractory or Severe Complicated Clostridium difficile Infection in Elderly Patients in Poor Medical Condition: The First Study in an Asian Country

Tae-Geun Gweon | Jinsu Kim | ... | Myung-Gyu Choi
  • Special Issue
  • - Volume 2016
  • - Article ID 8341030
  • - Research Article

Systemic and Splanchnic Lipopolysaccharide and Endothelin-1 Plasma Levels in Liver Cirrhosis before and after Transjugular Intrahepatic Portosystemic Shunt

Jiaxiang Meng | Qing Wang | ... | Xingjiang Wu
  • Special Issue
  • - Volume 2016
  • - Article ID 4953120
  • - Research Article

Treatment with a Monoclonal Anti-IL-12p40 Antibody Induces Substantial Gut Microbiota Changes in an Experimental Colitis Model

Josué Castro-Mejía | Maja Jakesevic | ... | Thomas L. Holm
  • Special Issue
  • - Volume 2016
  • - Article ID 5491465
  • - Review Article

Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms

Fengyuan Li | Kangmin Duan | ... | Wenke Feng
Gastroenterology Research and Practice
 Journal metrics
Acceptance rate25%
Submission to final decision63 days
Acceptance to publication29 days
CiteScore3.400
Impact Factor1.806
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