Liver cirrhosis leads to more than 1 million deaths per year, making it one of the major causes of death worldwide. It can cause many life-threatening complications, such as variceal bleeding, ascites and hydrothorax, infections, hepatic encephalopathy, and hepatocellular carcinoma.

Until now, the management of liver cirrhosis and its complications remains a clinical challenge. Researchers have made tremendous efforts to produce novel and convenient approaches during recent years. Recently, the Baveno VI criteria, including platelet count and liver stiffness, has been widely discussed for non-invasive diagnosis of esophageal varices needing treatment in compensated cirrhosis, which has greatly decreased the need for endoscopy and its discomfort. The PREDESCI randomized controlled trial has found the clinical benefits of the use of beta-blockers in compensated cirrhosis with early stages of portal hypertension. The ANSWER milestone clinical trial has opened a new window to recognize the importance of albumin infusion in decompensated cirrhosis. Considering more and more diagnostic and therapeutic advances in this field, it is essential for physicians and researchers to rapidly disseminate and realize the updated knowledge.

This Special Issue invites researchers to contribute original research and review articles to explore the assessment and treatment of liver cirrhosis. We are particularly interested in high-quality systematic reviews and meta-analyses.

Potential topics include but are not limited to the following:

• Noninvasive diagnosis of portal hypertension and esophageal varices
• Prognostic assessment of liver cirrhosis
• Assessment of renal function and management of acute kidney injury in liver cirrhosis
• Early use of terlipressin for complications of liver cirrhosis, especially in those with acute kidney injury
• Albumin use in the management of various complications of liver cirrhosis
• Assessment of cardiac function in liver cirrhosis and management of cirrhotic cardiomyopathy
• Assessment of nutritional status and management of malnutrition in liver cirrhosis
• Assessment and management of portal vein thrombosis in liver cirrhosis
• Novel endoscopic and interventional treatments for portal hypertension related complications in liver cirrhosis