Table of Contents Author Guidelines Submit a Manuscript

Diagnosis and Management of Gastroesophageal Reflux Disease

Call for Papers

Gastroesophageal reflux (GERD) is one of the most common disorders in medical practice. It is the most common gastrointestinal diagnosis recorded during visits to outpatient clinics in the United States. Apart from the economic burden of the disease and its impact on the quality of life, GERD is the most common predisposing factor for esophageal adenocarcinoma.

Recently, many important issues have emerged regarding the classification, pathogenesis, natural history, and treatment of GERD. Although proton pump inhibitors are effective in relieving reflux symptoms during initial treatment, most GERD patients need long-term treatment for frequent relapses after discontinuing acid inhibition therapy. This has led to great interest in new endoscopic therapies for the treatment of the disease. However, most of them were withdrawn soon after introduction due to the lack of long-term effects or the development of severe side effects. With regard to the diagnosis of GERD, patients with refractory reflux symptoms and normal upper endoscopy are more difficult to diagnose and treat. Combined 24 h pH and impedance monitoring allows classifying the patients as having true nonerosive reflux disease (NERD), hypersensitive esophagus, or functional heartburn and is helpful for further management of the patients.

The main focus of the special issue will focus on recent advances in the treatment of erosive esophagitis, NERD, and Barrett's esophagus. The emerging diagnostic methods, pharmacological treatments, and endoscopic therapies for GERD will be also introduced. Potential topics include, but are not limited to:

  • Pathogenesis of GERD
  • Current algorithms for the treatment of GERD
  • Update of NERD
  • Management of refractory GERD
  • Endoscopic therapy for Barrett's esophagus
  • Esophageal pH impedance monitoring in patients with therapy-resistant reflux symptoms

Before submission authors should carefully read over the journal's Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:

Manuscript DueFriday, 3 May 2013
First Round of ReviewsFriday, 26 July 2013
Publication DateFriday, 20 September 2013

Lead Guest Editor

  • Ping-I Hsu, Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, National Yang-Ming University, Kaohsiung 813, Taiwan

Guest Editors

  • Nayoung Kim, Division of Gastroenterology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
  • Khean Lee Goh, Department of Medicine, University of Malaysia, Kuala Lumpur, Malaysia
  • Deng-Chyang Wu, Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan