Gastroenterology Research and Practice

Toll-Like Receptor Signaling in Liver Diseases


Publishing date
15 Sep 2010
Status
Published
Submission deadline
15 Mar 2010

Lead Editor

1Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA

2Seattle Biomedical Research Institute, Seattle, WA 98109, USA

3Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA

4Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA

5Department of Molecular Microbiology and Immunology, University of Southern California School of Medicine, Los Angeles, CA 90033, USA


Toll-Like Receptor Signaling in Liver Diseases

Description

Toll-like receptors are the pattern recognition receptors that recognize microbes-derived products including bacterial-derived lipopolysaccharide and bacterial-derived DNA. This signaling mainly participates in host defense to eliminate invading microorganisms. Recent observations further suggest that Toll-like receptor signaling also contributes to noninfectious liver diseases including alcohol and nonalcoholic steatohepatitis, hepatic fibrosis, drug-induced hepatitis, autoimmune disease, and cancer in animal model. Moreover, several authors have shown that polymorphism of Toll-like receptors is associated with the severity of liver disease.

We invite authors to present original research articles as well as review articles that will stimulate the continuing efforts to define the role of Toll-like receptors in liver diseases. We are also interested in the recent advances regarding cytosolic pattern recognition receptors, RNA helicases in hepatitis C infection, and inflammasome-related molecules including NOD-like receptor family members, caspase-1, and ASC.

The papers that report therapies targeting Toll-like receptor signaling are also welcomed.

Potential topics include, but are not limited to:

  • Toll-like receptor signaling in specific cell types including Kupffer cells, NK cells, NKT cells, endothelial cells, hepatocytes, and stellate cells in the liver
  • Toll-like receptor signaling in infectious diseases in the liver
  • Toll-like receptor signaling in noninfectious diseases including ischemia/reperfusion injury, alcoholic, nonalcoholic steatohepatitis, fibrosis, and cancer in the liver
  • Toll-like receptors and RNA helicases in hepatitis B and C infection
  • Antagonists or agonists of Toll-like receptor signaling for the therapeutic potential for liver diseases
  • Toll-like receptor signaling in autoimmune disease including primary biliary cirrhosis and primary sclerosing cholangitis
  • Analyzing gene polymorphisms of Toll-like receptor signaling in liver diseases

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/grp/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 971270
  • - Editorial

Toll-Like Receptor Signaling in Liver Diseases

Gyongyi Szabo | Timothy R. Billiar | ... | Ekihiro Seki
  • Special Issue
  • - Volume 2010
  • - Article ID 518674
  • - Review Article

TLRs, Alcohol, HCV, and Tumorigenesis

Keigo Machida
  • Special Issue
  • - Volume 2010
  • - Article ID 548390
  • - Review Article

Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity

Helene Minyi Liu | Michael Gale
  • Special Issue
  • - Volume 2010
  • - Article ID 362847
  • - Review Article

Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease

Kouichi Miura | Ekihiro Seki | ... | David A. Brenner
  • Special Issue
  • - Volume 2010
  • - Article ID 240365
  • - Review Article

Current Views of Toll-Like Receptor Signaling Pathways

Masahiro Yamamoto | Kiyoshi Takeda
  • Special Issue
  • - Volume 2010
  • - Article ID 367694
  • - Review Article

NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis

Shin Maeda
  • Special Issue
  • - Volume 2010
  • - Article ID 598109
  • - Review Article

TLRs, NF- B, JNK, and Liver Regeneration

Yuji Iimuro | Jiro Fujimoto
  • Special Issue
  • - Volume 2010
  • - Article ID 750904
  • - Review Article

Toll-Like Receptor 3 in Liver Diseases

Shi Yin | Bin Gao
  • Special Issue
  • - Volume 2010
  • - Article ID 470468
  • - Review Article

SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases

Minoru Fujimoto | Tetsuji Naka
  • Special Issue
  • - Volume 2010
  • - Article ID 618260
  • - Review Article

TLRs in Hepatic Cellular Crosstalk

Amelie E. Bigorgne | Ian Nicholas Crispe
Gastroenterology Research and Practice
 Journal metrics
Acceptance rate29%
Submission to final decision68 days
Acceptance to publication32 days
CiteScore1.940
Impact Factor1.825
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