Table of Contents
Hepatitis Research and Treatment
Volume 2010, Article ID 182067, 8 pages
http://dx.doi.org/10.1155/2010/182067
Review Article

Rituximab Administration and Reactivation of HBV

1Department of Hematology, Hakodate Municipal Hospital, Hakodate 041-8680, Japan
2Department of Internal Medicine, Hakodate Municipal Hospital, 1-10-1 Minato-Cho, Hakodate 041-8680, Japan
3Department of Gastroenterology, Hakodate Municipal Hospital, Hakodate 041-8680, Japan
4Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan
5Department of Gastroentelology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan

Received 2 June 2010; Revised 3 September 2010; Accepted 29 September 2010

Academic Editor: Yoichi Hiasa

Copyright © 2010 Yutaka Tsutsumi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rituximab is a drug used for the treatment of B-cell non-Hodgkin's lymphoma, and its range of use has expanded to the treatment of collagen diseases such as idiopathic thrombocytopenic purpura and rheumatoid arthritis. One serious complication of rituximab use is the reactivation of dormant hepatitis B virus, and prevention of this phenomenon has become an urgent issue. This paper provides a general outline of the problem through an analysis of patient cases that we and other groups have experienced to date.