Table of Contents
Hepatitis Research and Treatment
Volume 2010, Article ID 323926, 4 pages
Review Article

Treatment of Hepatitis C Infections with Interferon: A Historical Perspective

Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA

Received 13 April 2010; Revised 2 July 2010; Accepted 30 July 2010

Academic Editor: Ming-Lung Yu

Copyright © 2010 Robert M. Friedman and Sara Contente. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Interferons were first described in 1957, but it was not until 34 years after their discovery that sufficient quantities of it were available for treatment of hepatitis C virus (HCV) infections, Clinicians now have an excellent understanding of the basis for the effectiveness of interferon alpha (IFN- 𝛼 ) in the therapy of this disease. Treatment with IFN- 𝛼 is more efficient when it complemented by the antiviral ribavirin and the IFN- 𝛼 is conjugated with polyethylene glycol to form peginterferon. In the near future treatment of HCV with IFN- 𝛼 may involve new anti-HCV agents that are currently under development.