Table of Contents
Hepatitis Research and Treatment
Volume 2011 (2011), Article ID 363205, 10 pages
http://dx.doi.org/10.1155/2011/363205
Research Article

Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia

1Grupo de Gastrohepatología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
2Instituto Tecnológico Metropolitano (ITM), Institución Universitaria Adscrita a la Alcaldía de Medellín, Medellín 549 59, Colombia
3Laboratorio de Virología Molecular, CMBC, Instituto Venezolano de Investigaciones Científicas, Apdo. 20632, Caracas 1020A, Venezuela, Caracas, Venezuela
4Unidad de Hepatología y Trasplante Hepático, Hospital Pablo Tobón Uribe (HPTU), Calle 78B 69-240, Medellín, Colombia
5Department of Virology, Swedish Institute for Infectious Disease Control, 171 82 Solna, Sweden

Received 21 March 2011; Accepted 21 July 2011

Academic Editor: Isabelle Chemin

Copyright © 2011 Fabian Cortes-Mancera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are the principal risk factor associated to end-stage liver diseases in the world. A study was carried out on end-stage liver disease cases admitted to an important hepatology unit in Medellin, the second largest city in Colombia. From 131 patients recruited in this prospective study, 71% of cases were diagnosed as cirrhosis, 12.2% as HCC, and 16.8% as cirrhosis and HCC. Regarding the risk factors of these patients, alcohol consumption was the most frequent (37.4%), followed by viral etiology (17.6%). Blood and/or hepatic tissue samples from patients with serological markers for HCV or HBV infection were characterized; on the basis of the phylogenetic analysis of HCV 5′ UTR and HBV S gene, isolates belonged to HCV/1 and HBV/F3, respectively. These results confirm the presence of strains associated with poor clinical outcome, in patients with liver disease in Colombia; additionally, HBV basal core promoter double mutant was identified in HCC cases. Here we show the first study of cirrhosis and/or HCC in Colombian and HBV and HCV molecular characterization of these patients. Viral aetiology was not the main risk factor in this cohort but alcohol consumption.