Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia

Table 3

Molecular characterization of HBV isolates corresponding to End-stage liver disease cases: Genotype, Subgenotype and precore/core mutants.

Code	Diagnosis	Genotype	Subgenotype	Mutation				HBV serological markers
				pre-C		BCP		HBsAg	IgG anti-HBc	HBeAg
				1858	1896	1762	1764
UdeA-009	Ci	F	F3^μ	—	—	—	—	Pos	Pos	Neg
UdeA-024	Ci	F	F1a^∞	T	G	A	G	Pos	Pos	Neg
UdeA-054	Ci	F	F3^∞	T	A^α	A	G	Pos	Pos	Neg
UdeA-056	HCC/Ci*	F	F3^μ	—	—	—	—	Pos	Pos	Neg
UdeA-083	HCC/Ci*	F	F3^∞	C	G	T*	A*	Pos	Pos	Neg
UdeA-089^β	HCC/Ci*	F	F3^∞	C	G	T*	A*	Pos	Pos	Neg

β: both, tissue and serum samples, Ci: cirrhosis, HCC/Ci*: cirrhosis and hepatocellular carcinoma, ∞: based on complete genome analysis, μ: based on S gene sequence analysis, —: no data, α: nonsense mutation, *: double mutant, Pos: positive, Neg: negative. Strains isolated from Colombian patients: UdeA-009, UdeA-024, UdeA-056, UdeA-083, and UdeA-089. Strain isolated from a Venezuelan patient: UdeA-54. 1.