Effects of HBV Genetic Variability on RNAi Strategies

Figure 2

A linear depiction of the HBV genome indicating successful RNAi target sites. Four main promoters (C, S1, S, and X promoters) and regulatory elements such as epsilon, EnhI, EnhII, PRE, and DR1 are indicated on the HBV genome. The four overlapping HBV ORFs are indicated as coloured solid boxes. Thin line represents HBV transcripts. The common poly(A) site is represented as “AAA.” Pink stars indicate Group I successful RNAi target sites, while green and blue stars represent Group II and Group III, respectively. The authors designated names of each of the RNA effectors indicated. Numbering indicates nucleotide position, using EcoRI-based numbering system from HBV Genotype A (AM282986, [6]).