Table of Contents
Hepatitis Research and Treatment
Volume 2012, Article ID 138302, 21 pages
Review Article

Hepatitis C Virus: A Critical Appraisal of New Approaches to Therapy

1Clinical and Translational Science Institute, University of Florida, 1600 SW Archer Road, Room M440, Medical Science Building, Gainesville, FL 32610, USA
2Center for Liver Diseases, University of Chicago Medical Center, Chicago, IL 60637, USA
3Viral Hepatitis Center, The Johns Hopkins University, Baltimore, MD 21218, USA
4University of Colorado Health Sciences Center, Aurora, CO 80262, USA
5University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
6Hepatology Section, Henry Ford Hospital, School of Medicine, Wayne State University, Detroit, MI 48201, USA
7Division of Gastroenterology and Hepatology, Center for the Study of Hepatitis C, Weill Medical College of Cornell, New York, NY 10065, USA
8Division of Digestive Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
9Division of Gastroenterology, Viral Hepatitis Center, University of California San Francisco, San Francisco, CA 94143, USA
10Infectious Diseases Viral Hepatitis Center, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA

Received 7 June 2012; Accepted 16 July 2012

Academic Editor: Piero Luigi Almasio

Copyright © 2012 David R. Nelson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The HCV council 2011 convened 11 leading clinicians and researchers in hepatitis C virus from academic medical centers in the United States to provide a forum for the practical and comprehensive evaluation of current data regarding best practices for integrating new direct-acting antiviral agents into existing treatment paradigms. The council investigated 10 clinical practice statements related to HCV treatment that reflect key topical areas. Faculty members reviewed and discussed the data related to each statement, and voted on the nature of the evidence and their level of support for each statement. In this new era of DAAs, a comprehensive and critical analysis of the literature is needed to equip clinicians with the knowledge necessary to design, monitor, and modify treatment regimens in order to optimize patient outcomes.