Hepatitis C Virus: A Critical Appraisal of New Approaches to Therapy

Table 8

Telaprevir Dosing in Treatment-Experienced Patients [5].

Telaprevir 750 mg taken orally 3 times a day (7–9 hours apart) with food in combination with PEG-IFN/RBV for 12 weeks
Prior Relapse Patients	TVR/PEG-IFN/RBV	PEG-IFN/RBV	Total Duration
HCV RNA undetectable at weeks 4 and 12	First 12 weeks	Additional 12 weeks	24 weeks
HCV-RNA detectable (1000 IU/mL or less) at weeks 4 and/or 12	First 12 weeks	Additional 36 weeks	48 weeks
Prior Partial and Null Responder Patients	First 12 weeks	Additional 36 weeks	48 weeks