Antioxidant Therapy in Nonalcoholic Steatohepatitis

Table 1

Published studies on the effects of vitamin E in patients with NAFLD.

Author	Year	Number	Intervention	Design	Durations (months)	Liver enzyme	Outcomes Fatty liver by imaging	Histology
Lavine et al. [41]	2011	57	Vitamin E versus metformin versus Placebo	RCT	24	NA	NA	Improved ballooning and NASH activity, no effect on lobular inflammation and fibrosis
Foster et al. [42]	2011		Atorvastatin and antioxidants (vitamins E + C) versus Placebo	RCT	48	NA	Improved steatosis on CT scans	NA
Sanyal et al. [40]	2010	247	Vitamin E versus pioglitazone versus placebo	RC T	24	Improved	NA	Improved steatosis and Inflammation (NS versus pioglitazone)
Dufour et al. [43]	2006	48	Vitamin E + UDCA versus UDCA + placebo versus placebo + placebo	RCT	24	Yes	NA	Steatosis improved
Kawanaka et al. [44]	2004	10	Vitamin E	Open label	6	Yes	NA	NA
Sanyal et al. [45]	2004	10	Vitamin E versus vitamin E + pioglitazone	RCT	6	Yes	NA	Yes
Vajro et al. [46]	2004	28	Vitamin E versus low calorie diet	RCT	5	Yes but NS	NA	No
Harrison et al. [47]	2003	49	Vitamin C + vitamin E + weight loss counselling	RCT	6	No	NA	Yes (fibrosis) No (inflammation/necrosis)
Kugelmas et al. [48]	2003	16	Vitamin E	RCT	3	Yes (NS)	NA	NA
Hasegawa et al. [49]	2001	12	Vitamin E	OL	12	Yes	NA	Yes
Lavine [50]	2000	11	Vitamin E	OL	4–10	Yes	NA	NA

N/A: not available; RCT: randomized controlled trial; OL: open label; NS: nonsignificant.