Involvement of Differential Relationship between HCV Replication and Hepatic PRR Signaling Gene Expression in Responsiveness to IFN-Based Therapy

Table 3

Correlations between HCV replication (liver positive- and negative-strand HCV RNAs and circulating HCV RNA) and hepatic PRR signaling gene expression regarding posttreatment virologic response.

Hepatic gene expression		Patients with SVR (𝑛=22)			Patients without SVR (𝑛=16)
		Liver HCV RNA		Serum HCV RNA	Liver HCV RNA		Serum HCV RNA
		+Strand	−Strand		+Strand	−Strand
TLR3 mRNA	𝑟	0.021	0.132	0.068	0.632	0.632	0.214
	𝑃	0.925	0.557	0.763	0.009	0.009	0.427
RIG-I mRNA	𝑟	0.192	0.243	−0.176	0.760	0.693	0.511
	𝑃	0.392	0.277	0.432	<0.001	0.003	0.043
TRIF mRNA	𝑟	0.109	0.200	−0.214	0.465	0.485	−0.029
	𝑃	0.631	0.373	0.339	0.069	0.057	0.914
IPS-1 mRNA	𝑟	0.072	0.131	−0.260	0.389	0.365	0.159
	𝑃	0.750	0.562	0.243	0.137	0.165	0.556
IRF3 mRNA	𝑟	0.056	0.023	−0.380	0.545	0.426	0.175
	𝑃	0.803	0.918	0.081	0.029	0.099	0.516
IFN-β mRNA	𝑟	0.034	−0.078	−0.107	0.158	0.112	−0.267
	𝑃	0.882	0.730	0.634	0.560	0.680	0.318