Hepatitis Research and Treatment / 2014 / Article / Tab 1

Research Article

MHC Class I Presented T Cell Epitopes as Potential Antigens for Therapeutic Vaccine against HBV Chronic Infection

Table 1

HBV specific MHC class I restricted peptides identified by immunoproteomics. The LC-MS/MS selection criteria for peptides are as follows: Charge 1: Xcorr > 1.6; Charge 2: Xcorr > 1.8; Charge 3: Xcorr > 2.0. The HLA binding scores were calculated using the SYFPEITHI prediction program [28].

Peptide sequenceProteinAccession IDHLA motif ChargeXcorrHLA binding score

GGPNLDNILLarge E Q8QSF2A245721.8813
LTFGRETVLENPrecore/core (C)Q6UFV9A264022.1819
LTTVPAASLLALarge E Q9YKJ7A253022.1220
ILRSFIPLLSurface (S)Q6WYY8A2/2453721.81A2: 28; A24: 12
FLKQQYMNLPolymerase (P)I0DE20A2/24118511.92A2: 20; A24: 9
FLSKQYMDLPolymerase (P)L7QBE1A2/A2457321.80A2: 21; A24: 11
TVSTKLCKIPolymerase (P)Q8B4E6A2/A2449721.92A2: 19; A24: 14
FLGGPPVCL Surface (S)Q0EED2A2/A2445222.05A2: 26; A24: 11

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