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Author, year, country | Study design | Association | Enrolled patients | Comments | Method of carotid atheromatosis assessment |
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Ishizaka et al., 2002 [14], Japan | Cross-sectional population based | Positive | 4784/104 HCV infected | First study in this field, measuring IMT | Ultrasonography IMT measurement |
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Tomiyama et al., 2003 [15], Japan | Cohort study | Positive | 7514/87 HCV infected | Increase arterial stiffness measured by pulse wave velocity | Pulse wave velocity |
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Mostafa et al., 2010 [16], Egypt | Cross-sectional | Positive | 329 anti-HCV positive/724 anti-HCV negative | Patients with active disease had higher risk compared to past infection | Ultrasonography IMT measurement |
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Petta et al., 2012 [6], Italy | Case control | Positive | 174 genotype 1 infected/174 controls | Association between fibrosis and the presence of plaques | Ultrasonography IMT > 1.3 mm |
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Adinolfi et al., 2012 [17], Italy | Case control | Positive | 803/326 HCV infected | Association between HCV steatosis and atheromatosis | Ultrasonography IMT: >1 mm or plaques ≥ 1.5 mm |
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Huang et al., 2013 [18], China | Meta-analysis | Positive | | Strongly correlates HCV infection to carotid atheromatosis | |
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Masia et al., 2011 [19], Spain | Cohort study | Negative | 138 HIV/63 HCV/HIV coinfected | No matching between exposed and control patients for any variable | Ultrasonography IMT > 1.0 mm |
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Caliskan et al., 2009 [20], Turkey | Prospective 59 months follow-up | Negative | 36 HCV infected/36 controls | No matching between exposed and control patients for any variable | Ultrasonography IMT > 1.0 mm |
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Tien et al., 2009 [21], USA | Cross-sectional | Negative | 1675/53 HCV monoinfected | HIV/HCV coinfection may be associated with a greater risk of carotid plaques | Ultrasonography Focal CIMT > 1.5 mm in any of the imaged segment |
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Völzke et al., 2004 [22], Germany | Cross-sectional | Negative | 4310/15 HCV infected | Very small number of HCV infected patients | Ultrasonography IMT measurement |
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