Table of Contents
Hepatitis Research and Treatment
Volume 2017 (2017), Article ID 1284273, 5 pages
Research Article

Prevalence of Hepatitis B Virus Infection among Pregnant Women Attending Antenatal Clinics in Vientiane, Laos, 2008–2014

1MIVEGEC, Université de Montpellier, CNRS 5290, IRD 224, Montpellier, France
2Oxford University Clinical Research Unit, Hanoi, Vietnam
3Institut de la Francophonie pour la Médecine Tropicale (IFMT), Vientiane, Laos
4Department of Infectious Diseases, Mahosot Hospital, Vientiane, Laos

Correspondence should be addressed to Yves Buisson

Received 24 January 2017; Revised 26 February 2017; Accepted 15 March 2017; Published 29 March 2017

Academic Editor: Annarosa Floreani

Copyright © 2017 Marc Choisy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The Lao People’s Democratic Republic (PDR) is still considered a highly endemic country for hepatitis B, mainly due to perinatal transmission of hepatitis B virus (HBV), despite efforts made since 2004 for universal immunization of newborns. The prevalence of HBV surface antigen (HBsAg) carriage in pregnant women is a relevant marker for the risk of mother-to-child HBV transmission. This study aimed to assess the changes in prevalence of HBV infection among pregnant women attending the Mahosot Prenatal Clinic (Vientiane Capital). Methods. A retrospective study was performed in the Mahosot Hospital Laboratory to collect and analyze all the results of HBsAg testing in pregnant women from 2008 to 2014. Results. Of a total of 13,238 tested women of mean age of 26 years, 720 women (5,44% [95 CI: 5.1–5.8%]) were found HBsAg positive, the annual prevalence ranging from 4.6% to 6.2%. A slight but steady and significant decrease in prevalence over the 7 years of the study could be documented. Conclusion. Although below the 8% hyperendemic threshold, the HBsAg prevalence observed in pregnant women in Vientiane reflects a high risk of HBV perinatal transmission and call for a widespread infant immunization with an HBV vaccine birth dose.