Clinical Study

Add-on Pegylated Interferon Alpha-2a Therapy in Chronic Hepatitis B Japanese Patients Treated with Entecavir

Table 4

Predictability of viral response.

Factors SensitivitySpecificityPPVNPVAccuracy

ALT (>20 IU/L)67% (8/12)64% (7/11)67% (8/12)64% (7/11)65% (15/23)
Reduction rate of HBs Ag at week 12 (>25%)75% (9/12)82% (9/11)82% (9/11)75% (9/12)78% (18/23)
Reduction rate of HBs Ag at week 16 (>30%)75% (9/12)82% (9/11)82% (9/11)75% (9/12)78% (18/23)

PPV, positive predictive value; NPV, negative predictive value; ALT, alanine aminotransferase; HBs Ag, hepatitis B antigen.