Hepatitis Research and Treatment

The Molecular Pathology and Clinical Impact of HBV Genetic Variability


Publishing date
01 Oct 2011
Status
Published
Submission deadline
01 Apr 2011

Lead Editor

1Institut National de la Santé et de la Recherche Médicale, Université Lyon, Lyon, France

2Section for Hepatitis and Enteroviruses, Department of Virology, Swedish Institute for Infectious Disease Control, Solana, Sweden

3INSERM U845, 156 rue de Vaugirard, 75015 Paris, France

4ICMR Virus Unit Kolkata, Indian Council of Medical Research, New Delhi, India


The Molecular Pathology and Clinical Impact of HBV Genetic Variability

Description

According to the World Health Organization, about 2 billion persons worldwide have been infected with Hepatitis B virus (HBV). More than 350 million are chronically infected worldwide with a high risk of developing liver cirrhosis and hepatocellular carcinoma (representing 1 million deaths per year).

Based on sequence divergence in the entire genome of >8%, HBV genomes have been classified into eight groups designated from A to H. The genotypes of HBV have distinct geographical distributions. Although preliminary clinical studies seem to indicate that there is an association between HBV genotype and natural history of infection and response to antiviral therapy, further evaluations on larger collectives of patients are necessary to give a clearer picture of the subject.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular pathology and clinical impact of HBV genetic variability. We are particularly interested in papers that explore this genetic variability in humans and animals and articles describing new options for diagnosis via immunoassays or molecular assays as well as any data that may help to understand the clinical impact of HBV variability. Potential topics include, but are not limited to:

  • Recent technical development of sensitive assays to detect HBV
  • Description of new HBV mutants and/or sub-genotypes
  • Role of genetic variability in relation to clinical picture, the response to treatment, and the long-term prognosis

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/heprt/guidelines.html. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 242106
  • - Editorial

The Molecular Pathology and Clinical Impact of HBV Genetic Variability

Isabelle Chemin | Heléne Norder | ... | Runu Chakravarty
  • Special Issue
  • - Volume 2011
  • - Article ID 582945
  • - Research Article

Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia

Maria-Cristina Navas | Iris Suarez | ... | Pierre Hainaut
  • Special Issue
  • - Volume 2011
  • - Article ID 363205
  • - Research Article

Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia

Fabian Cortes-Mancera | Carmen Luisa Loureiro | ... | Maria-Cristina Navas
  • Special Issue
  • - Volume 2011
  • - Article ID 475965
  • - Research Article

TP53 Mutations and HBX Status Analysis in Hepatocellular Carcinomas from Iran: Evidence for Lack of Association between HBV Genotype D and TP53 R249S Mutations

Behnoush Abedi-Ardekani | Doriane Gouas | ... | Pierre Hainaut
  • Special Issue
  • - Volume 2011
  • - Article ID 939148
  • - Research Article

Evolution of Hepatitis B Virus in a Chronic HBV-Infected Patient over 2 Years

Tao Shen | Xin-Min Yan | ... | Lin-Pin Wang
  • Special Issue
  • - Volume 2011
  • - Article ID 367908
  • - Review Article

Effects of HBV Genetic Variability on RNAi Strategies

Nattanan Panjaworayan | Chris M. Brown
  • Special Issue
  • - Volume 2011
  • - Article ID 697162
  • - Research Article

Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand

Olivier Galy | Isabelle Chemin | ... | Pierre Hainaut

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