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HPB Surgery
Volume 5, Issue 3, Pages 161-169
http://dx.doi.org/10.1155/1992/67843

Pharmacokinetics of Mitomycin C Following Hepatic Arterial Chemoembolization With Gelfoam

1Department of Surgery, Tongji Hospital, Tongji Medical University, Wuhan 430030, China
2Department of Surgery, Lund University, Lund S-221 85, Sweden

Received 1 June 1991; Accepted 1 June 1991

Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Twelve mongrel dogs were randomly allocated into two groups using matched paired-design. Catheters were inserted into the hepatic artery, hepatic vein and the femoral vein, respectively. In the first group, gelfoam supplemented with mitomycin C (MMC) was injected into the hepatic artery, whereas the second group received a hepatic arterial injection of MMC solution alone. Simultaneous blood sampling from the hepatic and femoral veins at regular intervals was performed. MMC concentrations in plasma was determined using high performance liquid chromatography (HPLC) and the pharmacokinetics of MMC were determined. MMC concentrations in hepatic and femoral veins did not differ and no significant difference in pharmacokinetics was found when comparing MMC administration into the hepatic artery with or without gelfoam supplementation. Thus, our results revealed that gelfoam could not delay the clearance of MMC from the liver.