HPB Surgery

HPB Surgery / 1994 / Article

Open Access

Volume 8 |Article ID 052975 | https://doi.org/10.1155/1994/52975

J. G. Geraghty, W. J. Angerson, D. C. Carter, "Splanchnic Haemodynamics and Vasoactive Agents in Experimental Cirrhosis", HPB Surgery, vol. 8, Article ID 052975, 6 pages, 1994. https://doi.org/10.1155/1994/52975

Splanchnic Haemodynamics and Vasoactive Agents in Experimental Cirrhosis


It is well known that portal hypertension is associated with a hyperdynamic systemic circulatory state. This study measures systemic and splanchnic haemodynamics in an experimental rat model of hepatic cirrhosis. It also investigates the association between haemodynamic changes in cirrhotic animals and circulating levels of the vasoactive hormones glucagon and vasoactive intestinal polypeptide (VIP). Splanchnic blood flow was significantly increased in the cirrhotic group (13.2 ± 1.3 vs. 9.2 ± 1.6 ml/min, P < 0.05). Circulating levels of glucagon and VIP were two and five fold increased respectively in cirrhotic animals compared to controls. There was a strong correlation between portal pressure and glucagon levels in the cirrhotic group (r = 0.85). Raised splanchnic blood flow is partly responsible for elevated portal pressure in this model and this rise may be humorally mediated.

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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