Table of Contents
HPB Surgery
Volume 11, Issue 6, Pages 363-371

Hepatobiliary Manifestations of Inflammatory Bowel Disease

1Department of Community Health, Guild NHS Trust and Lancashire Postgraduate Medical School, Preston, United Kingdom
2Department of Surgery, Queen's Medical Center, Nottingham, United Kingdom
3Astley House, Whitehall Road, Darwen, Lancashire BB3 2LH, United Kingdom

Received 21 November 1999

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hepatobiliary manifestations occur quite frequently in patients suffering from chronic ulcerative colitis and Crohn's disease and carry with them considerable morbidity and mortality. Although the true incidence is difficult to determine, clinically, significant hepatobiliary disease occurs in 5%–10% of patients. At the present moment, the aetiology and pathogenesis of inflammatory bowel disease and its systemic manifestations remains speculative. For those hepatobiliary manifestations that respond to therapy of the underlying bowel disease, medical and/or surgical therapy must be aggressively pursued. More urgent research is required towards understanding the underlying cause(s) of the primary bowel disease and its systemic manifestations in order to improve the overall management of this condition.