Table of Contents
HPB Surgery
Volume 2009, Article ID 835965, 8 pages
http://dx.doi.org/10.1155/2009/835965
Research Article

Influence of Portosystemic Shunt on Liver Regeneration after Hepatic Resection in Pigs

1Department of General, Visceral and Transplant Surgery, University Hospital Tübingen, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany
2Department of General and Transplant Surgery, University Hospital Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
3Department of Pathology, Academic Teaching Hospital, Carinagasse 47, 6800 Feldkirch, Austria

Received 5 January 2009; Revised 18 June 2009; Accepted 13 July 2009

Academic Editor: Guntars Pupelis

Copyright © 2009 R. Ladurner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Takahashi, P. S. Malchesky, and Y. Nose, “Artificial liver. State of the art,” Digestive Diseases and Sciences, vol. 36, no. 9, pp. 1327–1340, 1991. View at Google Scholar
  2. F. G. Court, S. A. Wemyss-Holden, A. R. Dennison, and G. J. Maddern, “The mystery of liver regeneration,” British Journal of Surgery, vol. 89, no. 9, pp. 1089–1095, 2002. View at Publisher · View at Google Scholar · View at PubMed
  3. C. J. Steer, “Liver regeneration,” The FASEB Journal, vol. 9, no. 14, pp. 1396–1400, 1995. View at Google Scholar
  4. N. Fausto, “Liver regeneration,” Journal of Hepatology, vol. 32, no. 1, pp. 19–31, 2000. View at Google Scholar
  5. C. D. Gove and R. D. Hughes, “Liver regeneration in relationship to acute liver failure,” Gut, vol. 32, pp. S92–S96, 1991. View at Google Scholar
  6. T. Kawasaki, F. Moriyasu, T. Kimura, H. Someda, Y. Fukuda, and K. Ozawa, “Changes in portal blood flow consequent to partial hepatectomy: doppler estimation,” Radiology, vol. 180, no. 2, pp. 373–377, 1991. View at Google Scholar
  7. Y.-D. Fan, M. Praet, J. Van Huysse, B. Lelie, and B. De Hemptinne, “Effects of portal vein arterialization on liver regeneration after partial hepatectomy in the rat,” Liver Transplantation, vol. 8, no. 2, pp. 146–152, 2002. View at Publisher · View at Google Scholar · View at PubMed
  8. G. K. Michalopoulos and M. C. DeFrances, “Liver regeneration,” Science, vol. 276, pp. 60–66, 1997. View at Google Scholar
  9. L. A. Nelson, D. P. O'Brien, C. J. Kemp et al., “Intestinal and hepatic response to combined partial hepatectomy and small bowel resection in mice,” American Journal of Surgery, vol. 183, no. 4, pp. 435–440, 2002. View at Publisher · View at Google Scholar
  10. K. Man, C.-M. Lo, I. O.-L. Ng et al., “Liver transplantation in rats using small-for-size grafts: a study of hemodynamic and morphological changes,” Archives of Surgery, vol. 136, no. 3, pp. 280–285, 2001. View at Google Scholar
  11. K. Man, S.-T. Fan, C.-M. Lo et al., “Graft injury in relation to graft size in right lobe live donor liver transplantation: a study of hepatic sinusoidal injury in correlation with portal hemodynamics and intragraft gene expression,” Annals of Surgery, vol. 237, no. 2, pp. 256–264, 2003. View at Publisher · View at Google Scholar
  12. S. Ueno, Y. Kobayashi, K. Kurita, G. Tanabe, and T. Aikou, “Effect of prior portosystemic shunt on early hepatic hemodynamics and sinusoids following 84% hepatectomy in dogs,” Research in Experimental Medicine, vol. 195, no. 1, pp. 1–8, 1995. View at Google Scholar
  13. M. Sahin, S. Tekin, F. Aksoy et al., “The effects of splenic artery ligation in an experimental model of secondary hypersplenism,” Journal of the Royal College of Surgeons of Edinburgh, vol. 45, no. 3, pp. 148–152, 2000. View at Google Scholar
  14. R. Troisi, G. Cammu, G. Militerno et al., “Modulation of portal graft inflow: a necessity in adult living-donor liver transplantation?” Annals of Surgery, vol. 237, no. 3, pp. 429–436, 2003. View at Publisher · View at Google Scholar
  15. T. Nishizaki, T. Ikegami, S. Hiroshige et al., “Small graft for living donor liver transplantation,” Annals of Surgery, vol. 233, no. 4, pp. 575–580, 2001. View at Publisher · View at Google Scholar
  16. O. Boillot, B. Delafosse, I. Méchet, C. Boucaud, and M. Pouyet, “Small-for-size partial liver graft in an adult recipient; a new transplant technique,” The Lancet, vol. 359, no. 9304, pp. 406–407, 2002. View at Publisher · View at Google Scholar · View at PubMed
  17. Y. Sato, S. Yamamoto, H. Oya et al., “Splenectomy for reduction of excessive portal hypertension after adult living-related donor liver transplantation,” Hepato-Gastroenterology, vol. 49, no. 48, pp. 1652–1655, 2002. View at Google Scholar
  18. R. Ladurner, G. Bodner, F. Offner, A. Krismer, R. Margreiter, and A. Königsrainer, “Extended hepatic resection and portosystemic shunt in pigs: a model for experimental liver regeneration,” European Surgery, vol. 38, no. 5, pp. 359–363, 2006. View at Publisher · View at Google Scholar
  19. C. Eipel, M. Glanemann, A. K. Nuessler, M. D. Menger, P. Neuhaus, and B. Vollmar, “Ischemic preconditioning impairs liver regeneration in extended reduced-size livers,” Annals of Surgery, vol. 241, no. 3, pp. 477–484, 2005. View at Publisher · View at Google Scholar
  20. V. E. Smyrniotis, G. Kostopanagiotou, K. Theodoraki et al., “Effect of mesocaval shunt on survival of small-for-size liver grafts: experimental study in pigs,” Transplantation, vol. 75, no. 10, pp. 1737–1740, 2003. View at Publisher · View at Google Scholar · View at PubMed
  21. B. Rocheleau, C. Éthier, R. Houle, P. M. Huet, and M. Bilodeau, “Hepatic artery buffer response following left portal vein ligation: its role in liver tissue homeostasis,” American Journal of Physiology, vol. 277, no. 5, pp. G1000–G1007, 1999. View at Google Scholar
  22. W. W. Lautt, “Regulatory processes interacting to maintain hepatic blood flow constancy: vascular compliance, hepatic arterial buffer response, hepatorenal reflex, liver regeneration, escape from vasoconstriction,” Hepatology Research, vol. 37, no. 11, pp. 891–903, 2007. View at Publisher · View at Google Scholar · View at PubMed
  23. J. Fujita, M. W. Marino, H. Wada et al., “Effect of TNF gene depletion on liver regeneration after partial hepatectomy in mice,” Surgery, vol. 129, no. 1, pp. 48–54, 2001. View at Publisher · View at Google Scholar
  24. J. Dłuzniewska, D. Zolich, J. Polański, L. Zajac, D. Sitkiewicz, and B. Łukomska, “Hepatocyte growth factor levels in liver and blood, and post-operative liver cell proliferation in patients with benign and malignant liver tumors after partial hepatectomy,” Medical Science Monitor, vol. 8, no. 10, pp. CR690–CR696, 2002. View at Google Scholar
  25. N. Fausto, A. D. Laird, and E. M. Webber, “Role of growth factors and cytokines in hepatic regeneration,” FASEB Journal, vol. 9, no. 15, pp. 1527–1536, 1995. View at Google Scholar
  26. H. Makino, S. Togo, T. Kubota et al., “A good model of hepatic failure after excessive hepatectomy in mice,” Journal of Surgical Research, vol. 127, no. 2, pp. 171–176, 2005. View at Publisher · View at Google Scholar · View at PubMed
  27. C. Corpechot, V. Barbu, D. Wendum et al., “Hepatocyte growth factor and c-Met inhibition by hepatic cell hypoxia: a potential mechanism for liver regeneration failure in experimental cirrhosis,” American Journal of Pathology, vol. 160, no. 2, pp. 613–620, 2002. View at Google Scholar
  28. N. De Paulsen, A. Brychzy, M.-C. Fournier et al., “Role of transforming growth factor-α in von Hippel-Lindau (VHL)-/- clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 4, pp. 1387–1392, 2001. View at Publisher · View at Google Scholar · View at PubMed
  29. T. Sato, O. N. El-Assal, T. Ono, A. Yamanoi, D. K. Dhar, and N. Nagasue, “Sinusoidal endothelial cell proliferation and expression of angiopoietin/Tie family in regenerating rat liver,” Journal of Hepatology, vol. 34, no. 5, pp. 690–698, 2001. View at Publisher · View at Google Scholar
  30. H. Shimizu, M. Miyazaki, Y. Wakabayashi et al., “Vascular endothelial growth factor secreted by replicating hepatocytes induces sinusoidal endothelial cell proliferation during regeneration after partial hepatectomy in rats,” Journal of Hepatology, vol. 34, no. 5, pp. 683–689, 2001. View at Publisher · View at Google Scholar
  31. J. W. Sturm, H. Zhang, R. Magdeburg et al., “Altered apoptotic response and different liver structure during liver regeneration in FGF-2-deficient mice,” Cellular Physiology and Biochemistry, vol. 14, no. 4-6, pp. 249–260, 2004. View at Publisher · View at Google Scholar · View at PubMed
  32. J. W. Sturm, M. Keese, H. Zhang et al., “Liver regeneration in FGF-2-deficient mice: VEGF acts as potential functional substitute for FGF-2,” Liver International, vol. 24, no. 2, pp. 161–168, 2004. View at Google Scholar
  33. M. Alison, “Liver stem cells: a two compartment system,” Current Opinion in Cell Biology, vol. 10, no. 6, pp. 710–715, 1998. View at Publisher · View at Google Scholar
  34. Y. Haruna, K. Saito, S. Spaulding, M. A. Nalesnik, and M. A. Gerber, “Identification of bipotential progenitor cells in human liver development,” Hepatology, vol. 23, no. 3, pp. 476–481, 1996. View at Google Scholar
  35. M. R. Alison, M. Golding, C. E. Sarraf, R. J. Edwards, and E.-N. Lalani, “Liver damage in the rat induces hepatocyte stem cells from biliary epithelial cells,” Gastroenterology, vol. 110, no. 4, pp. 1182–1190, 1996. View at Publisher · View at Google Scholar
  36. C. Liu, T. Schreiter, O. Dirsch et al., “Presence of markers for liver progenitor cells in human-derived intrahepatic biliary epithelial cells,” Liver International, vol. 24, no. 6, pp. 669–678, 2004. View at Publisher · View at Google Scholar · View at PubMed
  37. A. Katoonizadeh, F. Nevens, C. Verslype, J. Pirenne, and T. Roskams, “Liver regeneration in acute severe liver impairment: a clinicopathological correlation study,” Liver International, vol. 26, no. 10, pp. 1225–1233, 2006. View at Publisher · View at Google Scholar · View at PubMed
  38. J. A. Eleazar, L. Memeo, J. S. Jhang et al., “Progenitor cell expansion: an important source of hepatocyte regeneration in chronic hepatitis,” Journal of Hepatology, vol. 41, no. 6, pp. 983–991, 2004. View at Publisher · View at Google Scholar · View at PubMed