Table of Contents
HPB Surgery
Volume 2010, Article ID 627360, 5 pages
http://dx.doi.org/10.1155/2010/627360
Case Report

Pleomorphic Giant Cell Carcinoma of the Pancreas with Hepatic Metastases—Initially Presenting as a Benign Serous Cystadenoma: A Case Report and Review of the Literature

1Department of Hepatobilary Surgery, Churchill Hospital, Oxford OX3 7LJ, UK
2Department of Pathology, Medical School, University of Athens, Greece
3First Department of Surgery, Medical School, University of Athens, Greece
4Medical School, University of Athens, Greece

Received 20 October 2010; Accepted 30 November 2010

Academic Editor: J. R. Izbicki

Copyright © 2010 Petrou Athanasios et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. C. Sommers and W. A. Meissner, “Unusual carcinomas of the pancreas,” American Medical Association Archives of Pathology, vol. 58, no. 2, pp. 101–111, 1954. View at Google Scholar
  2. C. C. Leighton and D. T. Shum, “Osteoclastic giant cell tumor of the pancreas: case report and literature review,” American Journal of Clinical Oncology, vol. 24, no. 1, pp. 77–80, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. X. P. Zou, Z. L. Yu, Z. S. Li, and G. Z. Zhou, “Clinicopathological features of giant cell carcinoma of the pancreas,” Hepatobiliary and Pancreatic Diseases International, vol. 3, no. 2, pp. 300–302, 2004. View at Google Scholar · View at Scopus
  4. A. L. Mulkeen, P. S. Yoo, and C. Cha, “Less common neoplasms of the pancreas,” World Journal of Gastroenterology, vol. 12, no. 20, pp. 3180–3185, 2006. View at Google Scholar · View at Scopus
  5. G. H. Sakorafas and M. G. Sarr, “Cystic neoplasms of the pancreas; what a clinician should know,” Cancer Treatment Reviews, vol. 31, no. 7, pp. 507–535, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. C. Procacci, C. Biasiutti, G. Carbognin et al., “Characterization of cystic tumors of the pancreas: CT accuracy,” Journal of Computer Assisted Tomography, vol. 23, no. 6, pp. 906–912, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Sahani, S. Prasad, S. Saini, and P. Mueller, “Cystic pancreatic neoplasms evaluation by CT and magnetic resonance cholangiopancreatography,” Gastrointestinal Endoscopy Clinics of North America, vol. 12, no. 4, pp. 657–672, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. L. V. Hernandez, G. Mishra, C. Forsmark et al., “Role of endoscopic ultrasound (EUS) and EUS-guided fine needle aspiration in the diagnosis and treatment of cystic lesions of the pancreas,” Pancreas, vol. 25, no. 3, pp. 222–228, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. J. M. Scheiman, “Cystic lesion of the pancreas,” Gastroenterology, vol. 128, no. 2, pp. 463–469, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. J. A. Wargo, C. Fernandez-del-Castillo, and A. L. Warshaw, “Management of pancreatic serous cystadenomas,” Advances in Surgery, vol. 43, no. 1, pp. 23–34, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. H.-C. Oh, M.-H. Kim, C. Y. Hwang et al., “Cystic lesions of the pancreas: challenging issues in clinical practice,” American Journal of Gastroenterology, vol. 103, no. 1, pp. 229–240, 2008. View at Publisher · View at Google Scholar · View at PubMed
  12. L. A. van der Waaij, H. M. van Dullemen, and R. J. Porte, “Cyst fluid analysis in the differential diagnosis of pancreatic cystic lesions: a pooled analysis,” Gastrointestinal Endoscopy, vol. 62, no. 3, pp. 383–389, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. B. Moparty, R. Logroño, W. H. Nealon et al., “The role of endoscopic ultrasound and endoscopic ultrasound-guided fine-needle aspiration in distinguishing pancreatic cystic lesions,” Diagnostic Cytopathology, vol. 35, no. 1, pp. 18–25, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. J. F. Tseng, A. L. Warshaw, D. V. Sahani et al., “Serous cystadenoma of the pancreas: tumor growth rates and recommendations for treatment,” Annals of Surgery, vol. 242, no. 3, pp. 413–421, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Fujii, S. Kubo, K. Hirohashi, H. Kinoshita, T. Yamamoto, and K. Wakasa, “Serous cystadenoma of the pancreas with atypical cells: case report,” International Journal of Pancreatology, vol. 23, no. 2, pp. 165–169, 1998. View at Google Scholar · View at Scopus
  16. K. Kamei, T. Funabiki, M. Ochiai, H. Amano, M. Kasahara, and T. Sakamoto, “Case report: multifocal pancreatic serous cystadenoma with atypical cells and focal perineural invasion,” International Journal of Pancreatology, vol. 10, no. 2, pp. 161–172, 1991. View at Google Scholar · View at Scopus
  17. T. P. Tschang, R. Garza Garza, and J. M. Kissane, “Pleomorphic carcinoma of the pancreas. An analysis of 15 cases,” Cancer, vol. 39, no. 5, pp. 2114–2126, 1977. View at Google Scholar · View at Scopus
  18. M. Watanabe, H. Miura, H. Inoue et al., “Mixed osteoclastic/pleomorphic-type giant cell tumor of the pancreas with ductal adenocarcinoma: histochemical and immunohistochemical study with review of the literature,” Pancreas, vol. 15, no. 2, pp. 201–208, 1997. View at Google Scholar · View at Scopus
  19. J. C. Moore, K. Hilden, J. S. Bentz, R. K. Pearson, and D. G. Adler, “Osteoclastic and pleomorphic giant cell tumors of the pancreas diagnosed via EUS-guided FNA: unique clinical, endoscopic, and pathologic findings in a series of 5 patients,” Gastrointestinal Endoscopy, vol. 69, no. 1, pp. 162–166, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. A. Singhal, S. S. Shrago, S.-F. Li, Y. Huang, and V. Kohli, “Giant cell tumor of the pancreas: a pathological diagnosis with poor prognosis,” Hepatobiliary and Pancreatic Diseases International, vol. 9, no. 4, pp. 433–437, 2010. View at Google Scholar
  21. C. V. Reyes, S. Crain, and T. Wang, “Pleomorphic giant cell carcinoma of the pancreas: a review of nine cases,” Journal of Surgical Oncology, vol. 15, no. 4, pp. 345–348, 1980. View at Google Scholar · View at Scopus
  22. X. P. Zou, Z. L. Yu, Z. S. Li, and G. Z. Zhou, “Clinicopathological features of giant cell carcinoma of the pancreas,” Hepatobiliary and Pancreatic Diseases International, vol. 3, no. 2, pp. 300–302, 2004. View at Google Scholar · View at Scopus
  23. K. B. Lewandrowski, L. Weston, G. R. Dickersin, D. W. Rattner, and C. C. Compton, “Giant cell tumor of the pancreas of mixed osteoclastic and pleomorphic cell type: evidence for a histogenetic relationship and mesenchymal differentiation,” Human Pathology, vol. 21, no. 11, pp. 1184–1187, 1990. View at Publisher · View at Google Scholar · View at Scopus
  24. U. Oehler, M. Jürs, G. Klöppel, and B. Helpap, “Osteoclast-like giant cell tumour of the pancreas presenting as a pseudocyst-like lesion,” Virchows Archiv, vol. 431, no. 3, pp. 215–218, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Yamaguchi, H. Takahashi, R. Kagawa et al., “Huge pseudocyst of the pancreas caused by poorly differentiated invasive ductal adenocarcinoma with osteoclast-like giant cells: report of a case,” Hepato-Gastroenterology, vol. 54, no. 74, pp. 599–601, 2007. View at Google Scholar · View at Scopus
  26. G. Burkadze and G. Turashvili, “A case of osteoclast-like giant cell tumor of the pancreas associated with borderline mucinous cystic neoplasm,” Pathology and Oncology Research, vol. 15, no. 1, pp. 129–131, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. R. Scott, J. Jersky, and G. Hariparsad, “Malignant giant cell tumour of the pancreas presenting as a large pancreatic cyst,” British Journal of Radiology, vol. 66, no. 791, pp. 1055–1057, 1993. View at Google Scholar · View at Scopus