Table of Contents
HPB Surgery
Volume 2011, Article ID 327192, 4 pages
Case Report

A Malignant Gastrointestinal Stromal Tumor of the Gallbladder Immunoreactive for PDGFRA and Negative for CD 117 Antigen (c-KIT)

1Department of Hepatobilary Surgery, Churchill Hospital, Oxford OX3 7LJ, UK
2Hepatobiliary and Pancreatic Surgical Department, Oxford Radcliffe Hospitals NHS Foundation Trust OXford OX3 9DU, UK
3Department of Pathology, Medical School, University of Athens 11527 Athens, Greece
4First Department of Surgery, Medical School, University of Athens 11527 Athens, Greece

Received 24 September 2010; Accepted 27 January 2011

Academic Editor: Christos G. Dervenis

Copyright © 2011 Athanasios Petrou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Gastrointestinal stromal tumors (GISTs) compose the largest category of well-recognized nonepithelial neoplasms of the gastrointestinal tract (GI). GISTs of the gallbladder are extremely rare tumors. Only four malignant, two benign and one GIST-like tumor of the gall bladder have ever been described. The four malignant GISTs were all positive for CD 117 antigen (c-kit). We present for the first time a malignant gastrointestinal stromal tumor of the gallbladder, immunoreactive for platelet-derived growth factor receptor alpha (PDGFRA) and negative for CD 117 antigen (c-KIT).