The Dynamics of Glutathione Species and Ophthalmate Concentrations in Plasma from the VX2 Rabbit Model of Secondary Liver Tumors
Experimental design using the VX2 rabbit model of secondary liver tumors. The VX2 cell line was implanted in the muscle of F1 rabbits 4 weeks prior to tumor procurement. The experimental group was formed by rabbits where 1 mm3 tumor grafts were implanted in their liver. The Sham group consisted of rabbits that underwent similar operation, but 1 mm3 pieces of gelfoam were implanted in their liver. Enrichment of body water was achieved at 5% of total body water, and blood samples were taking at days −13, −12, and −11 prior to tumor implantation and at days +11, +12, and +13 after tumor implantation.
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