Ischemic Preconditioning of Rat Livers from Non-Heart-Beating Donors Decreases Parenchymal Cell Killing and Increases Graft Survival after Transplantation
Improved graft survival by ischemic preconditioning before aortic clamping. Anesthetized rats were given a sham operation (control) or ischemic preconditioning by clamping of the hepatic artery and portal vein for 10 min followed by 5 min of blood reperfusion (preconditioned). The aortas of the rats were then clamped for 60, 90, or 120 min. After clamping, livers were infused with cold UW solution, and stored for 2 h. After storage, livers were transplanted into recipient rats, and recipient survival after 30 days was determined. Numbers above the bars indicate survivors/total transplants. * versus control by Fisher’s exact test.
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