Minocycline Decreases Liver Injury after Hemorrhagic Shock and Resuscitation in Mice

Figure 2

Minocycline decreases necrosis after hemorrhage and resuscitation. H/R was performed, as described in Figure 1. Necrosis was assessed by H&E histology at 6 h after sham operation (a) or resuscitation with vehicle, minocycline, or tetracycline (b–d). In (e), necrosis as percent area in liver sections was averaged from 5 livers per treatment group. Necrosis in sham-operated mice was absent and not plotted. *, central vein. Bar is 100 μm. *𝑃<0.05 versus vehicle and tetracycline.

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(b)

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(e)