Table of Contents Author Guidelines Submit a Manuscript
HPB Surgery
Volume 2013 (2013), Article ID 689835, 6 pages
http://dx.doi.org/10.1155/2013/689835
Research Article

Intraportal versus Systemic Pentoxifylline Infusion after Normothermic Liver Ischemia: Effects on Regional Blood Flow Redistribution and Hepatic Ischemia-Reperfusion Injury

1Research Division, Heart Institute (InCor), University of Sao Paulo School of Medicine, 05403-900 Sao Paulo, SP, Brazil
2Hospital do Cancer de Muriae, Fundacao Cristiano Varella, 36880-000 Muriae, MG, Brazil
3Liver Transplant Unit, University of Sao Paulo School of Medicine, Avenida Dr Arnaldo 455, Suite 3206, 01246-903 Sao Paulo, SP, Brazil

Received 24 April 2013; Accepted 9 July 2013

Academic Editor: James Shapiro

Copyright © 2013 Edson A. Ribeiro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. F. Mahmoud, S. M. El Shazly, and W. Barakat, “Inhibition of TNF-α protects against hepatic ischemia-reperfusion injury in rats via NF-κB dependent pathway,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 385, no. 5, pp. 465–471, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. Y.-L. Yang, J.-P. Li, X.-P. Xu, K.-F. Dou, S.-Q. Yue, and K.-Z. Li, “Protective effects of tumor necrosis factor α antibody and ulinastatin on liver ischemic reperfusion in rats,” World Journal of Gastroenterology, vol. 10, no. 21, pp. 3161–3164, 2004. View at Google Scholar · View at Scopus
  3. L. M. Colletti, D. G. Remick, G. D. Burtch, S. L. Kunkel, R. M. Strieter, and D. A. Campbell Jr., “Role of tumor necrosis factor-α in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat,” Journal of Clinical Investigation, vol. 85, no. 6, pp. 1936–1943, 1990. View at Google Scholar · View at Scopus
  4. A. Aslan, G. Karagüzel, M. Çelik, N. Uysal, G. Yücel, and M. Melikoǧlu, “Pentoxifylline contributes to the hepatic cytoprotective process in rats undergoing hepatic ischemia and reperfusion injury,” European Surgical Research, vol. 33, no. 4, pp. 285–290, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Marteau, F. Ballet, Y. Chretien, C. Rey, P. Jaillon, and R. Poupon, “Effect of vasodilators on hepatic microcirculation: a study of the inhibition of norepinephrine-induced vasoconstriction in the isolated perfused rat liver,” Hepatology, vol. 8, no. 2, pp. 228–231, 1988. View at Google Scholar · View at Scopus
  6. E. Vardareli, T. Saricam, T. Koken, I. Degirmenci, E. Aral, and E. Erenoglu, “The effect of alpha-tocopherol and pentoxyfilline on ischemia-reperfusion induced liver injury in rats,” Hepato-Gastroenterology, vol. 45, no. 23, pp. 1505–1508, 1998. View at Google Scholar · View at Scopus
  7. L. Kaptanoglu, M. Kapan, S. Kapan, E. Goksoy, and H. Oktar, “Effects of nimodipine and pentoxyfylline in prevention of hepatic ischemic damage in rats at normal and hypothermic conditions,” European Journal of Pharmacology, vol. 587, no. 1–3, pp. 253–256, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. J. M. Müller, B. Vollmar, and M. D. Menger, “Pentoxifylline reduces venular leukocyte adherence (“reflow paradox”) but not microvascular “no reflow” in hepatic ischemia/reperfusion,” Journal of Surgical Research, vol. 71, no. 1, pp. 1–6, 1997. View at Publisher · View at Google Scholar · View at Scopus
  9. D. L. Mollitt and N. D. Poulos, “The role of pentoxifylline in endotoxin-induced alterations of red cell deformability and whole blood viscosity in the neonate,” Journal of Pediatric Surgery, vol. 26, no. 5, pp. 572–574, 1991. View at Publisher · View at Google Scholar · View at Scopus
  10. R. J. Cruz Jr., M. M. Yada-Langui, L. F. Poli-de-Figueiredo, S. Sinosaki, and M. Rocha-e-Silva, “The synergistic effects of pentoxifylline on systemic and regional perfusion after hemorrhage and hypertonic resuscitation,” Anesthesia and Analgesia, vol. 102, no. 5, pp. 1518–1524, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. M. M. Yada-Langui, E. A. Anjos-Valotta, P. Sannomiya, M. Rocha-e-Silva, and R. Coimbra, “Resuscitation affects microcirculatory polymorphonuclear leukocyte behavior after hemorrhagic shock: role of hypertonic saline and pentoxifylline,” Experimental Biology and Medicine, vol. 229, no. 7, pp. 684–693, 2004. View at Google Scholar · View at Scopus
  12. H.-I. Lin, S.-J. Chu, D. Wang, and N.-H. Feng, “Pharmacological modulation of TNF production in macrophages,” Journal of Microbiology, Immunology and Infection, vol. 37, no. 1, pp. 8–15, 2004. View at Google Scholar · View at Scopus
  13. Z. Tong, B. Chen, H. Dai, P. C. Bauer, J. Guzman, and U. Costabel, “Extrinsic allergic alveolitis: inhibitory effects of pentoxifylline on cytokine production by alveolar macrophages,” Annals of Allergy, Asthma and Immunology, vol. 92, no. 2, pp. 234–239, 2004. View at Google Scholar · View at Scopus
  14. R. Coimbra, A. Razuk-Filho, M. M. Yada-Langui, and M. Rocha-e-Silva, “Intraarterial pulmonary pentoxifylline improves cardiac performance and oxygen utilization after hemorrhagic shock: a novel resuscitation strategy,” Anesthesia and Analgesia, vol. 98, no. 5, pp. 1439–1446, 2004. View at Google Scholar · View at Scopus
  15. A. El-Ghoneimi, R. Cursio, A. Schmid-Alliana et al., “Pentoxifylline inhibits liver expression of tumor necrosis factor alpha mRNA following normothermic ischemia-reperfusion,” HPB, vol. 9, no. 2, pp. 112–119, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. A. El-Ghoneimi, R. Cursio, A. Schmid-Alliana et al., “Inhibition of tumor necrosis factor alpha gene transcription by pentoxifylline reduces normothermic liver ischemia-reperfusion injury in rats,” Transplantation Proceedings, vol. 39, no. 6, pp. 1761–1764, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. N. F. Cerqueira, C. A. Hussni, W. B. Yoshida, J. L. Sequeira, and C. R. Padovani, “Effects of pentoxifylline and n-acetylcysteine on injuries caused by ischemia and reperfusion of splanchnic organs in rats,” International Angiology, vol. 27, no. 6, pp. 512–521, 2008. View at Google Scholar · View at Scopus
  18. R. J. Cruz Jr., L. F. Poli-de-Figueiredo, J. L. M. Braz, E. A. Diniz, and M. Rocha-e-Silva, “Systemic and regional effects of supraceliac aortic occlusion during experimental hepatic vascular exclusion,” American Journal of Surgery, vol. 185, no. 4, pp. 388–393, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. E. A. Ribeiro, R. J. Cruz Jr., L. F. Poli-de-Figueiredo, O. Rojas, and M. Rocha-e-Silva, “Active spleno-femoral shunt avoids splanchnic congestion during portal triad occlusion: an experimental study,” Transplantation Proceedings, vol. 37, no. 5, pp. 2347–2350, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. R. J. Cruz Jr., A. G. Garrido, C. M. F. Ribeiro, T. Harada, and M. Rocha-e-Silva, “Regional blood flow distribution and oxygen metabolism during mesenteric ischemia and congestion,” Journal of Surgical Research, vol. 161, no. 1, pp. 54–61, 2010. View at Publisher · View at Google Scholar · View at Scopus