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HPB Surgery
Volume 2013, Article ID 875367, 7 pages
http://dx.doi.org/10.1155/2013/875367
Research Article

Renal Dysfunction Is an Independent Risk Factor for Mortality after Liver Resection and the Main Determinant of Outcome in Posthepatectomy Liver Failure

1Hepatobiliary Surgery, Plymouth Hospitals NHS Trust, Derriford Hospital, Derriford Road, Plymouth, Devon PL6 8DH, UK
2Peninsula College of Medicine and Dentistry, University of Exeter and Plymouth University, John Bull Building, Plymouth, Devon PL6 8BU, UK
3School of Science and Technology, Nottingham Trent University, Nottingham NG1 4BU, UK

Received 23 May 2013; Revised 5 September 2013; Accepted 24 September 2013

Academic Editor: Vito R. Cicinnati

Copyright © 2013 M. G. Wiggans et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. D. Mann, T. Palser, C. D. Briggs et al., “A review of factors predicting perioperative death and early outcome in hepatopancreaticobiliary cancer surgery,” HPB, vol. 12, no. 6, pp. 380–388, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Balzan, J. Belghiti, O. Farges et al., “The “50-50 criteria” on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy,” Annals of Surgery, vol. 242, no. 6, pp. 824–829, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Schreckenbach, J. Liese, W. O. Bechstein, and C. Moench, “Posthepatectomy liver failure,” Digestive Surgery, vol. 29, no. 1, pp. 79–85, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. F. Saner, “Kidney failure following liver resection,” Transplantation Proceedings, vol. 40, no. 4, pp. 1221–1224, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. M. A. J. van den Broek, S. W. M. O. Damink, C. H. C. Dejong et al., “Liver failure after partial hepatic resection: definition, pathophysiology, risk factors and treatment,” Liver International, vol. 28, no. 6, pp. 767–780, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. O. Farges, B. Malassagne, J. F. Flejou, S. Balzan, A. Sauvanet, and J. Belghiti, “Risk of major liver resection in patients with underlying chronic liver disease: a reappraisal,” Annals of Surgery, vol. 229, no. 2, pp. 210–215, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Belghiti, K. Hiramatsu, S. Benoist, P. P. Massault, A. Sauvanet, and O. Farges, “Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection,” Journal of the American College of Surgeons, vol. 191, no. 1, pp. 38–46, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Cucchetti, G. Ercolani, M. Vivarelli et al., “Impact of model for end-stage liver disease (MELD) score on prognosis after hepatectomy for hepatocellular carcinoma on cirrhosis,” Liver Transplantation, vol. 12, no. 6, pp. 966–971, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Dinant, W. de Graaf, B. J. Verwer et al., “Risk assessment of posthepatectomy liver failure using hepatobiliary scintigraphy and CT volumetry,” Journal of Nuclear Medicine, vol. 48, no. 5, pp. 685–692, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Karoui, C. Penna, M. Amin-Hashem et al., “Influence of preoperative chemotherapy on the risk of major hepatectomy for colorectal liver metastases,” Annals of Surgery, vol. 243, no. 1, pp. 1–7, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. L. McCormack, H. Petrowsky, W. Jochum, K. Furrer, and P. A. Clavien, “Hepatic steatosis is a risk factor for postoperative complications after major hepatectomy: a matched case-control study,” Annals of Surgery, vol. 245, no. 6, pp. 923–930, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. J. T. Mullen, D. Ribero, S. K. Reddy et al., “Hepatic insufficiency and mortality in 1,059 noncirrhotic patients undergoing major hepatectomy,” Journal of the American College of Surgeons, vol. 204, no. 5, pp. 854–862, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Slankamenac, S. Breitenstein, U. Held, B. Beck-Schimmer, M. A. Puhan, and P. Clavien, “Development and validation of a prediction score for postoperative acute renal failure following liver resection,” Annals of Surgery, vol. 250, no. 5, pp. 720–727, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Armstrong, F. K. S. Welsh, J. Wells, K. Chandrakumaran, T. G. John, and M. Rees, “The impact of pre-operative serum creatinine on short-term outcomes after liver resection,” HPB, vol. 11, no. 8, pp. 622–628, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. J. G. Abuelo, “Normotensive ischemic acute renal failure,” The New England Journal of Medicine, vol. 357, no. 8, pp. 797–805, 2007. View at Google Scholar · View at Scopus
  16. W. R. Jarnagin, M. Gonen, Y. Fong et al., “Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade,” Annals of Surgery, vol. 236, no. 4, pp. 397–407, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Imamura, Y. Seyama, N. Kokudo et al., “One thousand fifty-six hepatectomies without mortality in 8 years,” Archives of Surgery, vol. 138, no. 11, pp. 1198–1206, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. N. N. Rahbari, O. J. Garden, R. Padbury et al., “Posthepatectomy liver failure: a definition and grading by the international study group of liver surgery (ISGLS),” Surgery, vol. 149, no. 5, pp. 713–724, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Belghiti, P. A. Clavien, E. Gadzijev et al., “The Brisbane 2000 terminology of liver anatomy and resections,” HPB, vol. 2, no. 3, pp. 333–339, 2000. View at Google Scholar · View at Scopus
  20. G. P. Copeland, D. Jones, and M. Walters, “POSSUM: a scoring system for surgical audit,” The British Journal of Surgery, vol. 78, no. 3, pp. 355–360, 1991. View at Google Scholar · View at Scopus
  21. R. Bellomo, C. Ronco, J. A. Kellum, R. L. Mehta, and P. Palevsky, “Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the second international consensus conference of the acute dialysis quality initiative (ADQI) group,” Critical Care, vol. 8, no. 4, pp. R204–R212, 2004. View at Google Scholar · View at Scopus
  22. A. Agresti, An Introduction to Categorical Data Analysis, John Wiley & Sons, Hoboken, NJ, USA, 2nd edition, 2002.
  23. “‘R’—project for statistical computing,” 2011, http://www.r-project.org/.
  24. N. N. Rahbari, C. Reissfelder, M. Koch et al., “The predictive value of postoperative clinical risk scores for outcome after hepatic resection: a validation analysis in 807 patients,” Annals of Surgical Oncology, vol. 18, no. 13, pp. 3640–3649, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. R. M. Jones, C. E. Moulton, and K. J. Hardy, “Central venous pressure and its effect on blood loss during liver resection,” The British Journal of Surgery, vol. 85, no. 8, pp. 1058–1060, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. R. A. Schroeder, B. H. Collins, E. Tuttle-Newhall et al., “Intraoperative fluid management during orthotopic liver transplantation,” Journal of Cardiothoracic and Vascular Anesthesia, vol. 18, no. 4, pp. 438–441, 2004. View at Google Scholar · View at Scopus
  27. T. Kawai, Y. Yokoyama, M. Nagino, T. Kitagawa, and Y. Nimura, “Is there any effect of renal failure on the hepatic regeneration capacity following partial hepatectomy in rats?” Biochemical and Biophysical Research Communications, vol. 352, no. 2, pp. 311–316, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. S. A. Little, W. R. Jarnagin, R. P. DeMatteo, L. H. Blumgart, and Y. Fong, “Diabetes is associated with increased perioperative mortality but equivalent long-term outcome after hepatic resection for colorectal cancer,” Journal of Gastrointestinal Surgery, vol. 6, no. 1, pp. 88–94, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. G. K. Michalopoulos, “Liver regeneration,” Journal of Cellular Physiology, vol. 213, no. 2, pp. 286–300, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. I. R. Wanless and J. S. Lentz, “Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors,” Hepatology, vol. 12, no. 5, pp. 1106–1110, 1990. View at Publisher · View at Google Scholar · View at Scopus
  31. K. E. Behrns, G. G. Tsiotos, N. F. DeSouza, M. K. Krishna, J. Ludwig, and D. M. Nagorney, “Hepatic steatosis as a potential risk factor for major hepatic resection,” Journal of Gastrointestinal Surgery, vol. 2, no. 3, pp. 292–298, 1998. View at Google Scholar · View at Scopus
  32. Y. M. Sun, Y. Su, J. Li, and L. F. Wang, “Recent advances in understanding the biochemical and molecular mechanism of diabetic nephropathy,” Biochemical and Biophysical Research Communications, vol. 433, no. 4, pp. 359–361, 2013. View at Publisher · View at Google Scholar