Metabolomic Analysis of Liver Tissue from the VX2 Rabbit Model of Secondary Liver Tumors

Table 2

Table below shows the differentially expressed metabolites for the overall treatment effect (tumor-treated LT versus Sham-treated LG) with at most 10% FDR. Metabolites are ranked from top to bottom by (1) statistical significance (𝐵) and (2) magnitude of change (𝑀).

(a) 10 downregulated

Downregulated
	ID	𝑀=log2(FC)	FDR Adj.	𝐵=log2(Odds)
			𝑃 values
1	Uracil	−5.9822	4.52𝐸−53	141.4358
2	Erythriol	−5.0750	9.78𝐸−41	101.6021
3	𝛼-Hydroxyglutaric acid	−3.2867	2.28𝐸−19	42.2173
4	Salicylic acid	−2.8973	1.18𝐸−15	32.6557
5	Ethanolamine	−2.0405	1.38𝐸−08	15.8544
6	Glycolic acid	−1.1588	1.58𝐸−03	4.6512
7	Amino ethyl phosphate	−1.0952	2.72𝐸−03	4.0824
8	Citrate	−0.9941	6.46𝐸−03	3.2435
9	L-Serine	−0.6642	6.86𝐸−02	1.0709
10	D-ribose-5-phosphate	−0.6495	7.08𝐸−02	0.9943

(b) 6 up-regulated

Up-regulated
	ID	𝑀=log2(FC)	FDR Adj.	𝐵=log2(Odds)
			𝑃-values
1	Glucose	5.0586	1.08𝐸−40	100.9430
2	Glycerol	3.0981	1.55𝐸−17	37.4367
3	Threonic acid	2.3402	8.15𝐸−11	21.0678
4	Glycerol-3-P	1.6936	2.54𝐸−06	10.7094
5	O-acetylsalicylic acid	0.9825	6.62𝐸−03	3.1519
6	Inositol	0.7428	4.27𝐸−02	1.5101