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HPB Surgery
Volume 2014 (2014), Article ID 890530, 10 pages
http://dx.doi.org/10.1155/2014/890530
Research Article

The Association between Survival and the Pathologic Features of Periampullary Tumors Varies over Time

1Department of Surgery, Loyola University Health Systems, 2160 S. First Avenue, Maywood, IL 60153, USA
2Department of Pathology, Loyola University Health Systems, 2160 S. First Avenue, Maywood, IL 60153, USA
3Stritch School of Medicine, Loyola University Medical Center, 2160 S. First Avenue, Maywood, IL 60153, USA
4Department of Preventive Medicine, Loyola University Medical Center, 2160 S. First Avenue, Maywood, IL 60153, USA

Received 19 February 2014; Accepted 15 June 2014; Published 1 July 2014

Academic Editor: Harald Schrem

Copyright © 2014 Jennifer K. Plichta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. W. C. Chen, M. Bhandari, D. S. Astill et al., “Predicting patient survival after pancreaticoduodenectomy for malignancy: histopathological criteria based on perineural infiltration and lymphovascular invasion,” HPB, vol. 12, no. 2, pp. 101–108, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Cecchini, C. Correa-Gallego, V. Desphande et al., “Superior prognostic importance of perineural invasion vs. lymph node involvement after curative resection of duodenal adenocarcinoma,” Journal of Gastrointestinal Surgery, vol. 16, no. 1, pp. 113–120, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. J. H. Lee, K. G. Lee, H. Ryou et al., “Significance analysis of histologic type and perineural invasion as prognostic factors after curative resection of ampulla of vater carcinoma,” Hepato-Gastroenterology, vol. 57, no. 99-100, pp. 646–652, 2010. View at Google Scholar · View at Scopus
  4. M. H. van Roest, A. S. Gouw, P. M. Peeters et al., “Results of pancreaticoduodenectomy in patients with periampullary adenocarcinoma: perineural growth more important prognostic factor than tumor localization,” Annals of Surgery, vol. 248, no. 1, pp. 97–103, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. M. A. Talamini, R. C. Moesinger, H. A. Pitt et al., “Adenocarcinoma of the ampulla of Vater: a 28-year experience,” Annals of Surgery, vol. 225, no. 5, pp. 590–600, 1997. View at Publisher · View at Google Scholar · View at Scopus
  6. T. M. Pawlik, A. L. Gleisner, J. L. Cameron et al., “Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancer,” Surgery, vol. 141, no. 5, pp. 610–618, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. M. G. Hurtuk, C. Hughes, M. Shoup, and G. V. Aranha, “Does lymph node ratio impact survival in resected periampullary malignancies?” American Journal of Surgery, vol. 197, no. 3, pp. 348–352, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. O. Asoglu, H. Karanlik, M. Parlak et al., “Metastatic lymph node ratio is an independent prognostic factor in gastric cancer,” Hepato-Gastroenterology, vol. 56, no. 91-92, pp. 908–913, 2009. View at Google Scholar · View at Scopus
  9. Y. P. Liu, L. Ma, S. J. Wang et al., “Prognostic value of lymph node metastases and lymph node ratio in esophageal squamous cell carcinoma,” European Journal of Surgical Oncology, vol. 36, no. 2, pp. 155–159, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. M. J. Overman, C.-Y. Hu, R. A. Wolff, and G. J. Chang, “Prognostic value of lymph node evaluation in small bowel adenocarcinoma: analysis of the surveillance, epidemiology, and end results database,” Cancer, vol. 116, no. 23, pp. 5374–5382, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Rosenberg, J. Friederichs, T. Schuster et al., “Prognosis of patients with colorectal cancer Is associated with lymph node ratio a single-center analysis of 3026 patients over a 25-year time period,” Annals of Surgery, vol. 248, no. 6, pp. 968–978, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. S. C. Schiffman, K. M. McMasters, C. R. Scoggins, R. C. Martin, and A. B. Chagpar, “Lymph node ratio: a proposed refinement of current axillary staging in breast cancer patients,” Journal of the American College of Surgeons, vol. 213, no. 1, pp. 45–52, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Mocellin, S. Pasquali, C. Riccardo Rossi, and D. Nitti, “Validation of the prognostic value of lymph node ratio in patients with cutaneous melanoma: a population-based study of 8,177 cases,” Surgery, vol. 150, no. 1, pp. 83–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Bilici, B. B. O. Ustaalioglu, M. Gumus et al., “Is metastatic lymph node ratio superior to the number of metastatic lymph nodes to assess outcome and survival of gastric cancer?” Onkologie, vol. 33, no. 3, pp. 101–105, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. M. E. Danko, K. M. Bennett, J. Zhai, J. R. Marks, and J. A. Olson Jr., “Improved staging in node-positive breast cancer patients using lymph node ratio: results in 1,788 patients with long-term follow-up,” Journal of the American College of Surgeons, vol. 210, no. 5, pp. 797.e1–805.e1, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. E. A. Manilich, R. P. Kiran, T. Radivoyevitch, I. Lavery, V. W. Fazio, and F. H. Remzi, “A novel data-driven prognostic model for staging of colorectal cancer,” Journal of the American College of Surgeons, vol. 213, no. 5, pp. 579.e2–588.e2, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Rosenberg, J. Engel, C. Bruns et al., “The prognostic value of lymph node ratio in a population-based collective of colorectal cancer patients,” Annals of Surgery, vol. 251, no. 6, pp. 1070–1078, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Oshiro, R. Sasaki, A. Kobayashi et al., “Prognostic relevance of the lymph node ratio in surgical patients with extrahepatic cholangiocarcinoma,” European Journal of Surgical Oncology, vol. 37, no. 1, pp. 60–64, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Tamandl, K. Kaczirek, B. Gruenberger et al., “Lymph node ratio after curative surgery for intrahepatic cholangiocarcinoma,” British Journal of Surgery, vol. 96, no. 8, pp. 919–925, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Falconi, S. Crippa, I. Domínguez et al., “Prognostic relevance of lymph node ratio and number of resected nodes after curative resection of ampulla of Vater carcinoma,” Annals of Surgical Oncology, vol. 15, no. 11, pp. 3178–3186, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Murakami, K. Uemura, T. Sudo et al., “Number of metastatic lymph nodes, but not lymph node ratio, is an independent prognostic factor after resection of pancreatic carcinoma,” Journal of the American College of Surgeons, vol. 211, no. 2, pp. 196–204, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Sakata, Y. Shirai, T. Wakai, Y. Ajioka, K. Akazawa, and K. Hatakeyama, “Assessment of the nodal status in ampullary carcinoma: the number of positive lymph nodes versus the lymph node ratio,” World Journal of Surgery, vol. 35, no. 9, pp. 2118–2124, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. M. B. Slidell, D. C. Chang, J. L. Cameron et al., “Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: a large, population-based analysis,” Annals of Surgical Oncology, vol. 15, no. 1, pp. 165–174, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. T. N. Showalter, K. A. Winter, A. C. Berger et al., “The influence of total nodes examined, number of positive nodes, and lymph node ratio on survival after surgical resection and adjuvant chemoradiation for pancreatic cancer: a secondary analysis of RTOG 9704,” International Journal of Radiation Oncology, Biology and Physics, vol. 81, no. 5, pp. 1328–1335, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. C. E. Weber, E. A. Bock, M. G. Hurtuk et al., “Clinical and pathologic features influencing survival in patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma,” Journal of Gastrointestinal Surgery, vol. 18, no. 2, pp. 340–347, 2014. View at Google Scholar
  26. M. La Torre, M. Cavallini, G. Ramacciato et al., “Role of the Lymph node ratio in pancreatic ductal adenocarcinoma. Impact on patient stratification and prognosis,” Journal of Surgical Oncology, vol. 104, no. 6, pp. 629–633, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. J. C. Gutierrez, D. Franceschi, and L. G. Koniaris, “How many lymph nodes properly stage a periampullary malignancy?” Journal of Gastrointestinal Surgery, vol. 12, no. 1, pp. 77–85, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. S. G. Farid, G. A. Falk, D. Joyce et al., “Prognostic value of the lymph node ratio after resection of periampullary carcinomas,” HPB, vol. 16, no. 6, pp. 582–591, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Sierzega, T. Popiela, J. Kulig, and K. Nowak, “The ratio of metastatic/resected lymph nodes is an independent prognostic factor in patients with node-positive pancreatic head cancer,” Pancreas, vol. 33, no. 3, pp. 240–245, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. I. Hatzaras, N. George, P. Muscarella, W. S. Melvin, E. C. Ellison, and M. Bloomston, “Predictors of survival in periampullary cancers following pancreaticoduodenectomy,” Annals of Surgical Oncology, vol. 17, no. 4, pp. 991–997, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. J. M. Winter, M. F. Brennan, L. H. Tang et al., “Survival after resection of pancreatic adenocarcinoma: results from a single institution over three decades,” Annals of Surgical Oncology, vol. 19, no. 1, pp. 169–175, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. T. S. Riall, J. L. Cameron, K. D. Lillemoe et al., “Resected periampullary adenocarcinoma: 5-year survivors and their 6- to 10-year follow-up,” Surgery, vol. 140, no. 5, pp. 764–772, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Westgaard, S. Tafjord, I. N. Farstad et al., “Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma,” BMC Cancer, vol. 8, article 170, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. F. Ehehalt, P. Rümmele, S. Kersting et al., “Hepatocyte nuclear factor (HNF) 4α expression distinguishes ampullary cancer subtypes and prognosis after resection,” Annals of Surgery, vol. 254, no. 2, pp. 302–310, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. C. S. Verbeke, D. Leitch, K. V. Menon, M. J. McMahon, P. J. Guillou, and A. Anthoney, “Redefining the R1 resection in pancreatic cancer,” British Journal of Surgery, vol. 93, no. 10, pp. 1232–1237, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. C. S. Verbeke and I. P. Gladhaug, “Resection margin involvement and tumour origin in pancreatic head cancer,” British Journal of Surgery, vol. 99, no. 8, pp. 1036–1049, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. B. M. Rau, K. Moritz, S. Schuschan, G. Alsfasser, F. Prall, and E. Klar, “R1 resection in pancreatic cancer has significant impact on long-term outcome in standardized pathology modified for routine use,” Surgery, vol. 152, no. 3, supplement 1, pp. S103–S111, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. V. Chaudhary and S. Bano, “Imaging of the pancreas: recent advances,” Indian Journal of Endocrinology and Metabolism, vol. 15, supplement 1, pp. S25–S32, 2011. View at Google Scholar
  39. L. C. Fry, K. Mönkemüller, and P. Malfertheiner, “Molecular markers of pancreatic cancer: development and clinical relevance,” Langenbeck's Archives of Surgery, vol. 393, no. 6, pp. 883–890, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. G. Sandblom, S. Granroth, and I. C. Rasmussen, “TPS, CA 19-9, VEGF-A, and CEA as diagnostic and prognostic factors in patients with mass lesions in the pancreatic head,” Upsala Journal of Medical Sciences, vol. 113, no. 1, pp. 57–64, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. M. M. Aloysius, A. M. Zaitoun, S. Awad, M. Ilyas, B. J. Rowlands, and D. N. Lobo, “Mucins and CD56 as markers of tumour invasion and prognosis in periampullary cancer,” British Journal of Surgery, vol. 97, no. 8, pp. 1269–1278, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. M. C. Chang, Y. T. Chang, C. T. Sun, Y. F. Chiu, J. T. Lin, and Y. W. Tien, “Differential expressions of cyclin D1 associated with better prognosis of cancers of ampulla of vater,” World Journal of Surgery, vol. 31, no. 5, pp. 1135–1141, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. A. Tomazic, V. Pegan, K. Ferlan-Marolt, A. Pleskovic, and B. Luzar, “Cyclin D1 and bax influence the prognosis after pancreatoduodenectomy for periampullary adenocarcinoma,” Hepato-Gastroenterology, vol. 51, no. 60, pp. 1832–1837, 2004. View at Google Scholar · View at Scopus
  44. E. Tuncer, N. Şen Türk, S. Arici, S. E. Düzcan, and N. Çalli Demirkan, “Expression of p16 protein and cyclin D1 in periampullary carcinomas,” Turk Patoloji Dergisi, vol. 27, no. 1, pp. 17–22, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. M. Garzotto, T. M. Beer, R. G. Hudson et al., “Improved detection of prostate cancer using classification and regression tree analysis,” Journal of Clinical Oncology, vol. 23, no. 19, pp. 4322–4329, 2005. View at Publisher · View at Google Scholar · View at Scopus
  46. Y. Chang, L. Chen, K. Chung, and M. Lai, “Risk groups defined by Recursive Partitioning Analysis of patients with colorectal adenocarcinoma treated with colorectal resection,” BMC Medical Research Methodology, vol. 12, article 2, 2012. View at Publisher · View at Google Scholar · View at Scopus
  47. E. F. Cook and L. Goldman, “Empiric comparison of multivariate analytic techniques: advantages and disadvantages of recurrence partitioning analysis,” Journal of Chronic Diseases, vol. 37, no. 9-10, pp. 721–731, 1984. View at Publisher · View at Google Scholar · View at Scopus