Synthesis of Some New 1,2,4-Triazine and 1,2,5-Oxadiazine Derivatives with Antimicrobial Activity

Table 1

Antimicrobial activity of selected compounds.

Sample no.	Inhibition zone diameter (cm/gm sample)
	Staphylococcus aureus G+	Bacillus subtilis G+	Escherichia coli G−	Aspergillus niger (fungus)
2	00	00	00	15
3	13	15	00	00
6	12	14	00	00
7	11	00	00	00
Cip	15	20	16	—
CN	16	22	20	—
Am	—	—	—	17

Cip = ciprofloxacin (antibacterial agent); CN = erythromycin (antibacterial agent); Am = amphotericin (antifungal agent). The concentration of all synthesized compounds and the reference was 5 mg/1 ml of DMSO. Zone of inhibition: 0–16 mm = low; 14–16 mm = moderate; <16 mm = high; 0 = no inhibition.