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Infectious Diseases in Obstetrics and Gynecology
Volume 2, Issue 2, Pages 60-70
Review Article

Animal Models of Ascending Genital-Tract Infection in Pregnancy

1Department of Obstetrics and Gynecology, Kaiser Permanente, Denver, CO, USA
2University of Colorado Health Sciences Center, Denver, CO, USA
32045 Franklin Street, Denver, CO 80205-5494, USA

Received 25 March 1994; Accepted 16 June 1994

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This article reviews animal models currently used for investigation of ascending genital-tract infection in pregnancy. The specific models reviewed are those in the rabbit, monkey, and mouse. These models investigate both the direct effects of bacteria in the setting of ascending infection and the role of cytokines produced by the immune system. For each model, experiments that delineate the pathophysiology of ascending genital-tract infection in pregnancy are described. Intervention experiments, including the use of antibiotics, anti-inflammatory agents, immunotherapy, and anti-cytokine therapy, are described. Comparison of these models is made with respect to pathogenesis in humans, reproducibility, anatomy, and cost.