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Infectious Diseases in Obstetrics and Gynecology
Volume 3, Issue 1, Pages 28-33
Clinical Study

Single-Blind, Prospective, Randomized Study of Cefmetazole and Cefoxitin in the Treatment of Postcesarean Endometritis

1Department of Ob/Gyn/REI, Temple University Hospital, 3401 N. Broad Street, Philadelphia 19140, PA, USA
2University of Texas Medical Branch at Galveston, TX, USA
3University of California, San Francisco General Hospital, San Francisco, CA, USA
4University of New Mexico School of Medicine, Albuquerque, NM, USA
5Upjohn Company, Kalamazoo, MI, USA

Received 28 September 1994; Accepted 14 February 1995

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective: The purpose of this study was to compare the clinical efficacy and safety of cefmetazole given by IV push with that of parenterally administered cefoxitin for the treatment of endometritis following cesarean delivery.

Methods: In a single-blind, multicenter, prospective, randomized study, 355 patients with endometritis after cesarean delivery were enrolled and received medication. Administered was either cefmetazole sodium, 2 g by IV push over 1 min q 8 h, or cefoxitin sodium, 2 g IV q 6 h in a 2:1 ratio. The patients were followed for clinical responses and side effects.

Results: The cure rate for cefmetazole was 89% and for cefoxitin it was 79% (P = 0.006). The adverse events were similar in both groups.

Conclusions: Cefmetazole was significantly more effective than cefoxitin in the treatment of endometritis following cesarean delivery.