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Infectious Diseases in Obstetrics and Gynecology
Volume 4, Issue 2, Pages 89-91
Obstetrics Case Report

Human Immunodeficiency Virus-Associated Nephropathy in Pregnancy

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Health Science Center, Lyndon B. Johnson Hospital, 5656 Kelley, Houston 77026, TX, USA

Received 22 March 1996; Accepted 14 June 1996

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background: Human immunodeficiency virus (HIV)-associated nephropathy typically leads to endstage renal disease requiring dialysis within 3–4 months. This report describes the prenatal course of a patient with HIV-associated nephropathy requiring dialysis during pregnancy.

Case: A 23-year-old nulliparous, black female presented at 13 weeks gestation with a history of HIV-associated nephropathy and anemia. She had a CD4 count of 350/mm3, a total urinary protein of 1.7 g/day, and a serum creatinine of 4.8 mg/dl. The patient was begun on zidovudine, 500 mg daily, and erythropoietin, 4,000 units weekly. At 23 weeks gestation, when she developed hypertension, a total urinary protein of 3.4 g/day, and a serum creatinine of 4.4 mg/dl, she was hospitalized. Her renal function continued to deteriorate, requiring hemodialysis. At 29-4/7 weeks, she developed preterm labor, for which she was placed on indomethacin. Four days later, at 30 weeks gestation, she delivered a viable male infant.

Conclusion: HIV-associated nephropathy during pregnancy can be successfully managed with hemodialysis.