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Infectious Diseases in Obstetrics and Gynecology
Volume 5, Issue 4, Pages 297-302
Clinical Study

Six Years Observation After Successful Treatment of Bacterial Vaginosis

1Department of Obstetrics and Gynecology, Kärnsjukhuset, Skövde S-541 85, Sweden
2Department of Infectious Diseases and Clinical Microbiology, University of Uppsala, Uppsala, Sweden

Received 12 May 1997; Accepted 29 August 1997

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective: The cure rate after treatment of bacterial vaginosis (BV) differs in various investigations, but most studies report a cure rate of 70% after 1 month.

Methods: A long-term observation study after successful treatment of BV has been undertaken. The original study was a treatment study of BV and included 50 patients.

Results: We were able to identify 44 of the original 50 patients. The mean follow-up time was 6.9 years (range 4.7–9 years). During this time, 21 women (48%) had been free of BV while 23 women had had relapses. There was no difference in the use of broad-spectrum antibiotics, episodes of candida vaginitis, bleeding disturbances, family planning method, development of cervical intraepithelial neoplasia (CIN), or gynecological operations between women with and without relapses. The women with relapses had had a new sexual contact more often during the observation period than women without relapses. There was no difference in hydrogen peroxide production of the lactobacilli among women with or without relapses, and survival analysis shows that most relapses occur during the first year after treatment.

Conclusions: If patients are successfully treated, half of the patients will stay cured indicating that treatment is of benefit. Most relapses occur during the first year. Our results indicate that the etiology of BV might have something to do with new sexual contacts.