Infectious Diseases in Obstetrics and Gynecology

Infectious Diseases in Obstetrics and Gynecology / 1998 / Article

Research Article | Open Access

Volume 6 |Article ID 349161 | https://doi.org/10.1155/S1064744998000155

H. Mikamo, K. Kawazoe, K. Izumi, K. Watanabe, K. Ueno, T. Tamaya, "Studies on the Pathogenicity of Anaerobes, Especially Prevotella bivia, in a Rat Pyometra Model", Infectious Diseases in Obstetrics and Gynecology, vol. 6, Article ID 349161, 5 pages, 1998. https://doi.org/10.1155/S1064744998000155

Studies on the Pathogenicity of Anaerobes, Especially Prevotella bivia, in a Rat Pyometra Model

Received26 Oct 1995
Accepted11 May 1998

Abstract

Objective: Prevotella bivia is one of the anaerobic bacteria that resides in the flora of the female genital tract. We studied the pathogenicity of P. bivia in a rat pyometra model.Methods: The experimental animial (rat) model of pyometra was developed to investigate the pathogenicity of P. bivia in a rat pyometra model.Results: In the groups inoculated with aerobes alone, the infection rate was 10% (1/10) in the Staphylococcus aureus- or Staphylococcus agalactiae -inoculated group and 20% (2/10) in the Escherichia coli-inoculated group. Infection Was not established in the groups inoculated with anaerobes alone. High infection rates were observed in all the mixed-infection groups. In the S. agalactiae- and Bacteroides fragilis-, S. agalactiae- and P. bivia -, E. coli- and B. fragilis-, and E. coli- and P. biviai- inoculated groups, an infection rate of 100% (10/10) was demonstrated. The efficacy of antibiotics such as flomoxef (FMOX) could be determined using a rat pyometra model. In relation to the alteration of vaginal microbial flora during the menstrual cycle, estrogen increased the growth of P. bivia.Conclusion: Mixture of aerobic bacteria and P. bivia increased the pathogenicity of P. bivia. Estrogen would be useful for raising up the inflammatory change of the uterus in experimental models of genital tract infection due to P. bivia.

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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