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Infectious Diseases in Obstetrics and Gynecology
Volume 6, Issue 3, Pages 134-137
Obstetrical Case Report

Congenital Syphilis After Treatment of Maternal Syphilis With a Penicillin Regimen Exceeding CDC Guidelines

1Illinois Department of Public Health, Division of Infectious Diseases, 160 N. Lasalle Street, Chicago 60601, IL, USA
2Virginia Department of Health, Hampton Health District, Hampton, VA, USA
3Virginia Department of Health, Office of Epidemiology, Richmond, VA, USA
4Division of STD/HIV Prevention, NCHSTP, Centers for Disease Control and Prevention, Atlanta, GA, USA

Received 22 April 1998; Accepted 22 July 1998

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background: Although congenital syphilis usually occurs as a result of a failure to detect and treat syphilis in pregnant women, failures of the currently recommended regimen to prevent congenital syphilis have been reported.

Case: This report describes an infant with congenital syphilis despite maternal treatment with a regimen exceeding current CDC guidelines .

Conclusion: Regardless of the regimen used to treat syphilis during pregnancy, clinicians should recognize the possibility of occasional treatment failures and the importance of adequate follow-up of infants at risk for congenital syphilis.