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Infectious Diseases in Obstetrics and Gynecology
Volume 8 (2000), Issue 3-4, Pages 151-154

Use of Methergine for the Prevention of Postoperative Endometritis in Non-Elective Cesarean Section Patients

Department of Obstetrics and Gynecology, University of South Florida, College of Medicine, 4 Columbia Drive, Suite 500, Tampa 33606, FL, USA

Received 11 October 1999; Accepted 20 January 2000

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective: Methergine increases constriction of uterine musculature which may facilitate sloughing of endometrial debris, close uterine vessels, and prevent post-cesarean endometritis. The objective of this study was to evaluate the efficacy of methergine in preventing endometritis in patients undergoing non-elective cesarean section delivery.

Methods: Eighty patients undergoing non-elective cesarean section were enrolled in a prospective randomized clinical trial of methergine (41) versus no methergine (39) administration during the postpartum period. The hospital records were abstracted after discharge to compare the postpartum course.

Results: There were no significant demographic differences between the two groups. The women receiving methergine had a significant reduction in the rate of postoperative endometritis (10% vs. 36%, P < 0.005). In addition, the mean postoperative hemoglobin was significantly higher in the methergine treated group (P < 0.001).

Conclusions: The use of methergine postpartum in women undergoing non-elective cesarean sections significantly reduces the incidence of postoperative endometritis and blood loss. Infect. Dis. Obstet. Gynecol. 8:151–154; 2000.